PRKD3 - protein kinase D3 Gene

中文名称：蛋白激酶 D3

种属: Homo sapiens

同用名: EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU

基因 ID: 23683 | 基因类型: protein coding

关于 PRKD3

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,250,502-37,324,833 (from NCBI)

This gene has 10 transcripts (splice variants), 272 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 16.0), testis (RPKM 14.3) and 25 other tissues.

功能概要

该基因属于丝氨酸/苏氨酸激酶的多基因蛋白激酶 D 家族，可结合甘油二酯和佛波醇酯。该家族成员的特征在于 N 末端调节结构域，该结构域由富含半胱氨酸的锌指基序和 pleckstrin 结构域的串联重复组成。 C 端区域包含催化结构域并且与钙调节激酶远相关。这种酶的催化活性促进其核定位。这种蛋白质涉及多种功能，包括人类气道上皮屏障形成的负调节、乳腺癌和前列腺癌细胞的生长调节以及囊泡运输。[RefSeq 提供，2015 年 1 月]

This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this Enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate Cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

PRKD3 基因产物(9)

mRNA	Protein	Name
XM_047443852.1	XP_047299808.1	serine/threonine-protein kinase D3 isoform X1
XM_005264238.4	XP_005264295.1	serine/threonine-protein kinase D3 isoform X2
XM_005264237.5	XP_005264294.1	serine/threonine-protein kinase D3 isoform X1
XM_017003744.3	XP_016859233.1	serine/threonine-protein kinase D3 isoform X4
XM_047443856.1	XP_047299812.1	serine/threonine-protein kinase D3 isoform X5
NM_005813.6	NP_005804.1	serine/threonine-protein kinase D3
XM_047443855.1	XP_047299811.1	serine/threonine-protein kinase D3 isoform X4
XM_047443854.1	XP_047299810.1	serine/threonine-protein kinase D3 isoform X3
XM_047443853.1	XP_047299809.1	serine/threonine-protein kinase D3 isoform X1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables kinase activity	IDA IDA: 通过直接分析推断	22228765	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17196367	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKD3 蛋白结构

C1_1

Pkinase

0
200
400
600
800
890 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase D3

protein kinase C nu type

protein kinase EPK2

PRKD3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRKD3	O94806	VAMP2	Homo sapiens	P63027	Pull Down	17196367
种属内	PRKD3	O94806	VAMP2	Homo sapiens	P63027	Confocal	17196367
种属内	PRKD3	O94806	VAMP2	Homo sapiens	P63027	Y2H	17196367

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRKD3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73699	PRKD3/nPKC nu Protein, Human (sf9, GST)	O94806 (S2-P890)	≥95%

关联疾病

疾病名称

别名

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Conventional Lipoma

Classic Type Lipoma

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11148	PRKD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11149	Prkd3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11150	Prkd3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PRKD3	VGNC	VGNC:44988
Mus musculus	PRKD3	MGD	MGI:1922542
Bos taurus	PRKD3	VGNC	VGNC:33338
Rattus norvegicus	PRKD3	RGD	RGD:1310236
Macaca mulatta	PRKD3	VGNC	VGNC:76415
Felis catus	PRKD3	VGNC	VGNC:69066
Others	PRKD3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRKD3 - protein kinase D3 Gene

关于 PRKD3

功能概要

PRKD3 基因产物(9)

PRKD3 蛋白结构

PRKD3 蛋白互作信息

重组 PRKD3 蛋白

关联疾病

直系同源

热门区域

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PRKD3 - protein kinase D3 Gene

关于 PRKD3

功能概要

PRKD3 基因产物(9)

PRKD3 蛋白结构

PRKD3 蛋白互作信息

重组 PRKD3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z