2. Gene
  3. GSPT2 - G1 to S phase transition 2 Gene

GSPT2 - G1 to S phase transition 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G1 到 S 相变 2

种属: Homo sapiens

同用名: GST2; ERF3B

基因 ID: 23708 | 基因类型: protein coding

关于 GSPT2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:51,743,442-51,746,232 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 18 paralogues and is associated with 1 phenotype.

功能概要

该基因编码属于 GTP 结合延伸因子家族的 GTPase。编码的蛋白质是一种多肽释放因子，它与真核肽链释放因子 1 复合以介导翻译终止。这种蛋白质也可能参与 mRNA 稳定性。[RefSeq 提供，2010 年 3 月]

This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

GSPT2 基因产物(1)

mRNA Protein Name
NM_018094.5 NP_060564.2 eukaryotic peptide chain release factor GTP-binding subunit ERF3B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
15987998 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9712840 GOA
enables translation release factor activity IDA
IDA: 通过直接分析推断
15987998 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in translational termination IDA
IDA: 通过直接分析推断
15987998 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSPT2 蛋白结构

PAM2

PAM2: Ataxin-2 C-terminal region (47 - 64)

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (201 - 400)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (443 - 510)

GTP_EFTU_D3

GTP_EFTU_D3: Elongation factor Tu C-terminal domain (520 - 623)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 628 a.a.
蛋白主名 其他名称

eukaryotic peptide chain release factor GTP-binding subunit ERF3B

eukaryotic peptide chain release factor subunit 3b

GSPT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GSPT2 Q8IYD1 UPF1 Homo sapiens Q92900
Anti Bait CoIP
18447585
Intra GSPT2 Q8IYD1 UPF1 Homo sapiens Q92900
Anti Tag CoIP
33961781
Intra GSPT2 Q8IYD1 ETF1 Homo sapiens P62495
Anti Tag CoIP
33961781
Intra GSPT2 Q8IYD1 ETF1 Homo sapiens P62495
Anti Tag CoIP
28514442
Intra GSPT2 Q8IYD1 PABPC1 Homo sapiens P11940
Anti Tag CoIP
23340509
Intra GSPT2 Q8IYD1 PABPC1 Homo sapiens P11940
Anti Tag CoIP
33961781
Intra GSPT2 Q8IYD1 PABPC1 Homo sapiens P11940
Anti Tag CoIP
18447585
Intra GSPT2 Q8IYD1 PABPC1 Homo sapiens P11940
ITC
14685257
Intra GSPT2 Q8IYD1 PABPC1 Homo sapiens P11940
Anti Bait CoIP
18447585
Intra GSPT2 Q8IYD1 PABPC1 Homo sapiens P11940
Pull Down
18447585
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Treacher Collins Syndrome 3

TCS3

Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal Recessive

Mandibulofacial Dysostosis Treacher Collins Type Autosomal Recessive
Leukodystrophy, Hypomyelinating, 11

Hypomyelinating Leukodystrophy 11

HLD11

4h Leukodystrophy 3

Leukodystrophy, Hypomyelinating, Type 11
Chromosome Xp11.22 Duplication Syndrome

Mrx17

Mental Retardation, X-Linked 31

Mrx31

Xp11.22 Microduplication Syndrome

X-Linked Mental Retardation 31

Mental Retardation, X-Linked 17
Brugada Syndrome 5

BRGDA5

Cardiac Conduction Defect, Nonspecific

Brugada Syndrome, Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150259 MDEG-541 Degrader 98.05% 否
HY-161101 MG degrader 1 Degrader 99.83% 否
HY-RS05869 GSPT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GSPT2 MGD MGI:1316727
Rattus norvegicus GSPT2 RGD RGD:1563213
Bos taurus GSPT2 VGNC VGNC:106763
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