2. Gene
  3. ETF1 - eukaryotic translation termination factor 1 Gene

ETF1 - eukaryotic translation termination factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译终止因子 1

种属: Homo sapiens

同用名: ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1

基因 ID: 2107 | 基因类型: protein coding

关于 ETF1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,506,095-138,543,236 (from NCBI)

This gene has 9 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in bone marrow (RPKM 46.6), esophagus (RPKM 37.2) and 25 other tissues.

功能概要

该基因编码 1 类多肽链释放因子。编码的蛋白质在指导从终止密码子 UAA、UAG 和 UGA 终止 mRNA 翻译中起着重要作用。这种蛋白质是 SURF 复合体的一个组成部分，它通过无义介导的 mRNA 衰变 (NMD) 机制促进过早终止的 mRNA 的降解。交替剪接导致多个转录本变体。该基因的假基因存在于染色体 6、7 和 X 上。[RefSeq 提供，2013 年 8 月]

This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

ETF1 基因产物(6)

mRNA Protein Name
NM_001256302.2 NP_001243231.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001282185.2 NP_001269114.1 eukaryotic peptide chain release factor subunit 1 isoform 3
NM_001291974.2 NP_001278903.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001291975.2 NP_001278904.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001364160.2 NP_001351089.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_004730.4 NP_004721.1 eukaryotic peptide chain release factor subunit 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminoacyl-tRNA hydrolase activity IDA
IDA: 通过直接分析推断
16777602 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9620853 GOA
enables sequence-specific mRNA binding IMP
IMP: 通过突变表型推断
12909007 GOA
enables translation release factor activity IDA
IDA: 通过直接分析推断
7990965 GOA
enables translation termination factor activity IDA
IDA: 通过直接分析推断
10445876 GOA
enables translation termination factor activity IMP
IMP: 通过突变表型推断
24486019 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within protein methylation IDA
IDA: 通过直接分析推断
18539146 GOA
involved in regulation of translational termination IMP
IMP: 通过突变表型推断
30682371 GOA
acts upstream of or within translational termination IDA
IDA: 通过直接分析推断
7990965 GOA
involved in translational termination IDA
IDA: 通过直接分析推断
10445876 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12426392 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
10445876 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
12426392 GOA
part of translation release factor complex IDA
IDA: 通过直接分析推断
26245381 GOA
part of translation release factor complex IPI
IPI: 通过物理相互作用推断
19417105 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ETF1 蛋白结构

eRF1_1

eRF1_1: eRF1 domain 1 (9 - 139)

eRF1_2

eRF1_2: eRF1 domain 2 (145 - 277)

eRF1_3

eRF1_3: eRF1 domain 3 (280 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
蛋白主名 其他名称

eukaryotic peptide chain release factor subunit 1

polypeptide chain release factor 1

ETF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ETF1 P62495 GSPT2 Homo sapiens Q8IYD1
Anti Tag CoIP
18447585
种属内
ETF1 P62495 KEAP1 Homo sapiens Q14145
Y2H Pooling
16189514
种属内
ETF1 P62495 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
种属内
ETF1 P62495 KEAP1 Homo sapiens Q14145
Validated Y2H
32296183
种属内
ETF1 P62495 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
种属内
ETF1 P62495 GSPT1 Homo sapiens P15170
3D-EM
24335085
种属内
ETF1 P62495 GSPT1 Homo sapiens P15170
3D-EM
23091004
种属内
ETF1 P62495 GSPT1 Homo sapiens P15170
Anti Tag CoIP
18256688
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis

Hme

Human Ehrlichial Infection, Human Monocytic Type
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome

Aarrs

Limb/Pelvis-Hypoplasia/Aplasia Syndrome

LPHAS

Schinzel Type Phocomelia

Absence Of Ulna And Fibula With Severe Limb Deficiency

Al-Awadi/Raas-Rothschild Syndrome

Al Awadi-Raas-Rothschild Syndrome

Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

Aplasia/Hypoplasia Of Limbs And Pelvis

Congenital Absence Of Ulna And Fibula

Severe Limb Deficit

Phocomelia, Schinzel Type

Al-Awadi-Raas-Rothschild Syndrome

Ulna And Fibula Absence Of With Severe Limb Deficiency

Limb Pelvis Hypoplasia Aplasia Syndrome

Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Bone Chondrosarcoma
Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis

Hge

Human Ehrlichial Infection, Human Granulocytic Type

Human Anaplasmosis Due To Anaplasma Phagocytophilum
Ehrlichiosis

Human Ehrlichiosis

He

Hey
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04554 ETF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ETF1 VGNC VGNC:84370
Felis catus ETF1 VGNC VGNC:97422
Bos taurus ETF1 VGNC VGNC:28617
Mus musculus ETF1 MGD MGI:2385071
Rattus norvegicus ETF1 RGD RGD:1305712
Others ETF1 NCBI
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