2. Gene
  3. GSPT1 - G1 to S phase transition 1 Gene

GSPT1 - G1 to S phase transition 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G1 到 S 相变 1

种属: Homo sapiens

同用名: GST1; ETF3A; eRF3a; 551G9.2

基因 ID: 2935 | 基因类型: protein coding

关于 GSPT1

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,868,128-11,916,654 (from NCBI)

This gene has 10 transcripts (splice variants), 283 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 16.3), colon (RPKM 15.7) and 25 other tissues.

功能概要

启用翻译释放因子活动。参与翻译终止的调节。作用于蛋白质甲基化的上游或内部。预测位于胞质溶胶中。预计是翻译释放因子复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. [provided by Alliance of Genome Resources, Apr 2022]

GSPT1 基因产物(3)

mRNA Protein Name
NM_001130006.2 NP_001123478.2 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2
NM_001130007.2 NP_001123479.1 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3
NM_002094.4 NP_002085.3 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
15987998 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9620853 GOA
enables translation release factor activity IDA
IDA: 通过直接分析推断
15987998 GOA
enables translation release factor activity IMP
IMP: 通过突变表型推断
15326224 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within protein methylation IDA
IDA: 通过直接分析推断
18539146 GOA
involved in regulation of translational termination IMP
IMP: 通过突变表型推断
30682371 GOA
involved in translational termination IDA
IDA: 通过直接分析推断
15987998 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
15987998 GOA
part of translation release factor complex IDA
IDA: 通过直接分析推断
27863242 GOA
part of translation release factor complex IPI
IPI: 通过物理相互作用推断
19417105 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSPT1 蛋白结构

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (72 - 271)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (314 - 381)

GTP_EFTU_D3

GTP_EFTU_D3: Elongation factor Tu C-terminal domain (391 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
蛋白主名 其他名称

eukaryotic peptide chain release factor GTP-binding subunit ERF3A

G1 to S phase transition protein 1 homolog

GSPT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GSPT1 P15170 UPF1 Homo sapiens Q92900
Anti Tag CoIP
35271311
种属内
GSPT1 P15170 ETF1 Homo sapiens P62495
Anti Tag CoIP
35271311
种属内
GSPT1 P15170 ETF1 Homo sapiens P62495
Anti Tag CoIP
18256688
种属内
GSPT1 P15170 PABPC1 Homo sapiens P11940
Anti Tag CoIP
35271311
种属内
GSPT1 P15170 PABPC1 Homo sapiens P11940
Anti Tag CoIP
18256688
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Duane-Radial Ray Syndrome

Okihiro Syndrome

DRRS

Dr Syndrome

Duane Anomaly With Radial Ray Abnormalities And Deafness

Acrorenoocular Syndrome

Acrorenocular Syndrome

Duane Anomaly With Radial Abnormalities And Deafness

Acro-Renal-Ocular Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-130800 Eragidomide 99.86% Phase 2
HY-153356 MRT-2359 Inducer 99.98% Phase 2
Pre-clinical Phase
生物活性分子 (34)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101488 CC-885 99.85% 否
HY-132199 SJ6986 Degrader 98.00% 否
HY-145448 MC-VC-PABC-amide-PEG1-CH2-CC-885 99.93% 否
HY-151902 SJ988497 98.05% 否
HY-147158 ZXH-1-161 Modulator 98.43% 否
HY-130122 MG-277 Inducer 98.66% 否
HY-164202 ORM-5029 99.60% 否
HY-153803 GBD-9 Inhibitor 99.76% 否
HY-136688 MI-389 99.34% 否
HY-150616 SJPYT-195 99.41% 否
HY-150259 MDEG-541 Degrader 98.05% 否
HY-161101 MG degrader 1 Degrader 99.83% 否
HY-170952 LYG-409 Degrader / 否
HY-143435 AG6033 Inducer / 否
HY-148837 PROTAC c-Myc degrader-1 / 否
HY-155552 GSPT1 degrader-1 / 否
HY-156747 GSPT1 degrader-2 / 否
HY-157426 GSPT1 degrader-3 Degrader / 否
HY-159609 PROTAC GSPT1 degrader-1 / 否
HY-159610 PROTAC GSPT1 degrader-2 / 否
HY-159619 Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl / 否
HY-159620 Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl / 否
HY-159622 Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl / 否
HY-159623 Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl / 否
HY-161696 AN5777 Inducer / 否
HY-162533 GSPT1 degrader-4 Degrader / 否
HY-162534 GSPT1 degrader-5 Degrader / 否
HY-162535 GSPT1 degrader-6 Inhibitor / 否
HY-163938A PROTAC erf3a Degrader-2 / 否
HY-168936 DP-15 / 否
HY-170405 YB-3–17 Inhibitor / 否
HY-170820 XYD049 / 否
HY-RS05868 GSPT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W599025 5-Br-4-Cl-Pyrrolo-pyroxypyridine / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GSPT1 MGD MGI:1316728
Canis familiaris GSPT1 VGNC VGNC:41533
Felis catus GSPT1 VGNC VGNC:67487
Rattus norvegicus GSPT1 RGD RGD:2751
Macaca mulatta GSPT1 VGNC VGNC:73300
Bos taurus GSPT1 VGNC VGNC:29681
Others GSPT1 NCBI
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