FLRT3 - fibronectin leucine rich transmembrane protein 3 Gene

中文名称：纤连蛋白富亮氨酸跨膜蛋白 3

种属: Homo sapiens

同用名: HH21

基因 ID: 23767 | 基因类型: protein coding

关于 FLRT3

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:14,322,985-14,337,612 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 12.2), lung (RPKM 9.3) and 16 other tissues.

功能概要

该基因编码富含亮氨酸的纤连蛋白跨膜蛋白 (FLRT) 家族的成员。 FLRT 可能在细胞粘附和/或受体信号传导中起作用。它们的蛋白质结构类似于细胞外基质中发现的富含亮氨酸的小蛋白聚糖。该基因在许多组织中表达。已针对该基因描述了编码相同蛋白质的两个可变剪接转录物变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

FLRT3 基因产物(2)

mRNA	Protein	Name
NM_013281.4	NP_037413.1	leucine-rich repeat transmembrane protein FLRT3 precursor
NM_198391.3	NP_938205.1	leucine-rich repeat transmembrane protein FLRT3 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	26235030	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	26235030	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IDA IDA: 通过直接分析推断	26235030	GOA
involved in neuron projection extension	IMP IMP: 通过突变表型推断	14706654	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	14706654	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FLRT3 蛋白结构

LRR_8

0
100
200
300
400
500
600
649 a.a.

蛋白主名

其他名称

leucine-rich repeat transmembrane protein FLRT3

fibronectin-like domain-containing leucine-rich transmembrane protein 3

FLRT3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FLRT3	Q9NZU0	ADGRL3	Homo sapiens	Q9HAR2	BLI	26235030
种属内	FLRT3	Q9NZU0	ADGRL3	Homo sapiens	Q9HAR2	GMS	26235030
种属内	FLRT3	Q9NZU0	ADGRL3	Homo sapiens	Q9HAR2	X-Ray Diffraction	26235030

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FLRT3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70924	FLRT3 Protein, Human (HEK293, His)	Q9NZU0 (K29-P528)	≥95%

关联疾病

疾病名称

别名

Hypogonadotropic Hypogonadism 21 With Or Without Anosmia

HH21	Hypogonadotropic Hypogonadism 21 With Anosmia
Hypogonadotropic Hypogonadism 21 With Anosmia, Susceptibility To	Hypogonadism, Hypogonadotropic, Type 21 With/Without Anosmia

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Hypogonadism

Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia	ECTD4
Ectodermal Dysplasia, Pure Hair-Nail Type	Ectodermal Dysplasia, 'Pure' Hair/Nail Type
Hned	Hair-Nail Ectodermal Dysplasia
Phned	Ectodermal Dysplasia Pure Hair-Nail Type
Ectodermal Dysplasia, 'Pure' Hair-Nail Type	Dysplasia, Ectodermal, Type 4, Hair/Nail

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04986	FLRT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	FLRT3	VGNC	VGNC:29040
Felis catus	FLRT3	VGNC	VGNC:82430
Rattus norvegicus	FLRT3	RGD	RGD:1566005
Canis familiaris	FLRT3	VGNC	VGNC:40906
Mus musculus	FLRT3	MGD	MGI:1918686
Macaca mulatta	FLRT3	VGNC	VGNC:72677
Others	FLRT3	NCBI

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