Mmp17 - matrix metallopeptidase 17 Gene

中文名称：基质金属肽酶 17

种属: Mus musculus

同用名: MT4MMP; MTMMP4; MT4-MMP

关于 Mmp17

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工，产生成熟的锌依赖性内肽酶。缺乏编码蛋白的小鼠表现出功能失调的血管平滑肌细胞和血管壁中细胞外基质的改变，导致对血管紧张素-II 诱导的胸主动脉瘤的易感性增加。 [RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016]