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  3. Pde10a - phosphodiesterase 10A Gene

Pde10a - phosphodiesterase 10A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 10A

种属: Mus musculus

基因 ID: 23984 | 基因类型: protein coding

关于 Pde10a

Chromosome 17: 8,744,204-9,205,480 forward strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 27 phenotypes. Biased expression in CNS E18 (RPKM 7.5), cortex adult (RPKM 4.9) and 13 other tissues.

功能概要

该基因编码的蛋白可启动 3',5'-环状核苷酸磷酸二酯酶活性。在调节腺苷酸环化酶激活 G 蛋白偶联受体信号通路和调节蛋白激酶 A 信号通路的上游或调节内起作用。预测位于膜和核周。在消化系统中表达；心血管系统;神经系统;和感觉器官。与人 PDE10A（磷酸二酯酶 10A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of protein kinase A signaling. Predicted to be located in membrane and perikaryon. Is expressed in alimentary system; cardiovascular system; nervous system; and sensory organ. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Apr 2022]

Pde10a 基因产物(3)

mRNA Protein Name
NM_001290707.1 NP_001277636.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
NM_001347321.1 NP_001334250.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3
NM_011866.2 NP_035996.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IDA
IDA: 通过直接分析推断
10359840 MGI
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IMP
IMP: 通过突变表型推断
27058446 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
18923023 MGI
acts upstream of or within regulation of cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
18923023 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
31171447 MGI
is active in synapse IDA
IDA: 通过直接分析推断
31171447 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde10a 蛋白结构

GAF

GAF: pfam01590 (100 - 243)

GAF

GAF: smart00065 (276 - 431)

PDEase_I

PDEase_I: pfam00233 (523 - 754)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
蛋白主名 其他名称

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12472 Balipodect Inhibitor 99.47% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-50098A Mardepodect hydrochloride Inhibitor 99.94% Phase 2
Pre-clinical Phase
生物活性分子 (25)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-50098 Mardepodect Inhibitor 99.04% 否
HY-153093 MK-8189 Inhibitor 99.88% 否
HY-14550 TP-10 Inhibitor 99.88% 否
HY-12913 AMG 579 Inhibitor 99.02% 否
HY-117604 THPP-1 Inhibitor 98.75% 否
HY-135848 N-Methylbenzamide Inhibitor 99.93% 否
HY-18078 PQ-10 Inhibitor 99.77% 否
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% 否
HY-10030 Mardepodect succinate / 否
HY-10568 TC-E 5005 Inhibitor / 否
HY-123743 JNJ-42314415 Inhibitor / 否
HY-152838 Gemlapodect Inhibitor / 否
HY-158237 PDE10A-IN-3 Inhibitor / 否
HY-160111 PDM-042 Inhibitor / 否
HY-161663 Phosphodiesterase-IN-2 Inhibitor / 否
HY-18037 AMG-7980 / 否
HY-RS10199 PDE10A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117838 Phosphodiesterase 10-IN-2 Inhibitor / 否
HY-123154 PDE10A-IN-4 / 否
HY-123446 JNJ-42259152 / 否
HY-124392 AMG580 Antagonist / 否
HY-W003486 5,7-Dichloropyrazolo[1,5-a]pyrimidine Inhibitor / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde10a NCBI NCBI:10846
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