Nr3c1 - nuclear receptor subfamily 3, group C, member 1 Gene

中文名称：核受体亚家族 3 ，C 组，成员 1

种属: Rattus norvegicus

同用名: GR; Gcr; Grl

关于 Nr3c1

功能概要

该基因编码的蛋白可启动多种功能，包括热休克蛋白结合活性；受体酪氨酸激酶结合活性；和转录共激活因子活性。参与多个过程，包括细胞对镁离子的反应；染色质组织；和对糖皮质激素的反应。位于细胞质中；树突棘;和突触后密度。部分含蛋白质复合物。在谷氨酸能突触和突触后密度、细胞内成分中具有活性。与细胞核共定位。用于研究多种疾病，包括哮喘；充血性心力衰竭;高血压;肥胖;和 2 型糖尿病。多种疾病的生物标志物，包括脑部疾病（多种）；晚期肾脏疾病;肌肉萎缩;多囊卵巢综合征;和创伤后应激障碍。该基因的人类直系同源物与多种疾病有关，包括神经性厌食症；肺部疾病（多发）；严重抑郁症;肥胖;和肾细胞癌。与人类 NR3C1（核受体亚家族 3 C 组成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to magnesium ion; chromatin organization; and response to glucocorticoid. Located in cytoplasm; dendritic spine; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with nucleus. Used to study several diseases, including asthma; congestive heart failure; hypertension; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including brain disease (multiple); end stage renal disease; muscular atrophy; polycystic ovary syndrome; and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]