2. Gene
  3. Grm5 - glutamate metabotropic receptor 5 Gene

Grm5 - glutamate metabotropic receptor 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酸代谢受体 5

种属: Rattus norvegicus

同用名: mGluR5; mGlur5

基因 ID: 24418 | 基因类型: protein coding

关于 Grm5

Primary_assembly 1: 141,312,368-141,882,274 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 11 phenotypes. Restricted expression toward (RPKM 246.3).

功能概要

该基因编码的蛋白可启动 A2A 腺苷受体结合活性；谷氨酸受体活性；和蛋白酪氨酸激酶结合活性。参与多个过程，包括G蛋白偶联受体信号通路；调节信号转导；和跨突触信号。位于星形胶质细胞投影；树突;和突触后密度膜。在谷氨酸能突触中活跃。是突触后膜的组成部分。与人类 GRM5（谷氨酸代谢受体 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables A2A Adenosine Receptor binding activity; glutamate receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and trans-synaptic signaling. Located in astrocyte projection; dendrite; and postsynaptic density membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 基因产物(1)

mRNA Protein Name
NM_017012.2 NP_058708.1 metabotropic glutamate receptor 5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables A2A adenosine receptor binding IPI
IPI: 通过物理相互作用推断
12189203 RGD
enables glutamate receptor activity IMP
IMP: 通过突变表型推断
1320017 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12189203 RGD
enables protein tyrosine kinase activator activity IGI
IGI: 通过遗传相互作用推断
24012003 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
24012003 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
1320017 RGD
involved in chemical synaptic transmission IMP
IMP: 通过突变表型推断
12514208 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
12514208 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15758184 RGD
involved in positive regulation of long-term neuronal synaptic plasticity IDA
IDA: 通过直接分析推断
12740378 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15758184 RGD
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12189203 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte projection IDA
IDA: 通过直接分析推断
21753079 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
18582438 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
18582438 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
8758956 RGD
located in neuron projection IDA
IDA: 通过直接分析推断
15829628 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15829628 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
8758956 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Grm5 蛋白结构

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (25 - 495)

NCD3G

NCD3G: pfam07562 (506 - 556)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 601)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 825)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (613 - 634)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (643 - 667)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (691 - 711)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (734 - 760)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (768 - 791)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (794 - 819)

Herpes_BLLF1

Herpes_BLLF1: cl37540 (1012 - 1170)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1152 - 1202)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1203 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 5

glutamate receptor, metabotropic 5

metabotropic glutamate receptor (mGluR5)

metabotropic glutamate receptor 5b

Grm5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Grm5 P31424 Tamalin Rattus norvegicus Q8R4T5
SPR
17396155
种属内
Grm5 P31424 Tamalin Rattus norvegicus Q8R4T5
Anti Tag CoIP
17396155
种属内
Grm5 P31424 Ppp1cc Rattus norvegicus P63088
CoIP
14519764
种属内
Grm5 P31424 Ppp1cc Rattus norvegicus P63088
Pull Down
14519764
种属内
Grm5 P31424 Ppp1cc Rattus norvegicus P63088
Y2H
14519764
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05831 GRM5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05832 Grm5 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05833 Grm5 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm5 NCBI NCBI:2915
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