2. Gene
  3. Idh1 - isocitrate dehydrogenase (NADP(+)) 1 Gene

Idh1 - isocitrate dehydrogenase (NADP(+)) 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：异柠檬酸脱氢酶 (NADP (+)) 1

种属: Rattus norvegicus

同用名: IDPc

基因 ID: 24479 | 基因类型: protein coding

关于 Idh1

Primary_assembly 9: 66,534,146-66,563,708 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 231 orthologues, 1 paralogue and is associated with 38 phenotypes. Biased expression in Liver (RPKM 1633.7), Kidney (RPKM 1182.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 NADP 结合活性和异柠檬酸脱氢酶 (NADP+) 活性。参与女性性腺发育；异柠檬酸代谢过程；和对类固醇激素的反应。位于过氧化物酶体中。该基因的人类直系同源物与自身免疫性疾病有关；血液系统癌症（多发性）；肝细胞透明细胞癌；和高级神经胶质瘤（多发）。与人类 IDH1（异柠檬酸脱氢酶 (NADP(+)) 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NADP binding activity and isocitrate dehydrogenase (NADP+) activity. Involved in female gonad development; isocitrate metabolic process; and response to steroid hormone. Located in peroxisome. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic Cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]

Idh1 基因产物(1)

mRNA Protein Name
NM_031510.1 NP_113698.1 isocitrate dehydrogenase [NADP] cytoplasmic
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NADP binding IDA
IDA: 通过直接分析推断
17447164 RGD
enables isocitrate dehydrogenase (NADP+) activity IDA
IDA: 通过直接分析推断
17447164 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 2-oxoglutarate metabolic process IDA
IDA: 通过直接分析推断
16489927 RGD
involved in female gonad development IEP
IEP: 通过表达模式推断
8083215 RGD
involved in isocitrate metabolic process IDA
IDA: 通过直接分析推断
17447164 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
8486157 RGD
involved in response to steroid hormone IDA
IDA: 通过直接分析推断
8349575 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in peroxisome IDA
IDA: 通过直接分析推断
14561759 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Idh1 蛋白结构

PTZ00435

PTZ00435: PTZ00435 (0 - 410)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
蛋白主名 其他名称

isocitrate dehydrogenase [NADP] cytoplasmic

IDH

IDP

Isocitrate dehydrogenase 1, soluble

NADP(+)-specific ICDH

cytosolic NADP-isocitrate dehydrogenase

isocitrate dehydrogenase (NADP(+)) 1, cytosolic

isocitrate dehydrogenase 1 (NADP+), soluble

oxalosuccinate decarboxylase

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-104042 Vorasidenib Inhibitor 99.87% 是
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-114226 Olutasidenib Inhibitor 99.16% Phase 2
HY-104036 IDH-305 Inhibitor 98.75% Phase 2
HY-145594 Safusidenib Inhibitor / Phase 2
HY-131312 Crelosidenib Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19540 GSK864 Inhibitor 99.91% 否
HY-18082 AGI-5198 Inhibitor 99.77% 否
HY-128661 IDH1 Inhibitor 2 Inhibitor 99.40% 否
HY-12475 Mutant IDH1-IN-1 Inhibitor 99.43% 否
HY-128888 (R,R)-GSK321 Inhibitor 99.31% 否
HY-128888B (S,R)-GSK321 Inhibitor 98.78% 否
HY-150238 IDH1 Inhibitor 7 Inhibitor 99.46% 否
HY-149359 IHMT-IDH1-053 Inhibitor / 否
HY-110144 TC-E 5008 Inhibitor / 否
HY-158319 Mutant IDH1/NAMPT-IN-1 Inhibitor / 否
HY-162631 IDH1 Inhibitor 9 Inhibitor / 否
HY-120765 BRD2879 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Idh1 NCBI NCBI:3417
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