2. Gene
  3. Ncam1 - neural cell adhesion molecule 1 Gene

Ncam1 - neural cell adhesion molecule 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cd56; Ncam; N-CAM; NCAMC; NCAM-1; NCAM-C; N-CAM-1

基因 ID: 24586 | 基因类型: protein coding

关于 Ncam1

功能概要

Enables LRR domain binding activity and Phosphatase binding activity. Involved in several processes, including axon development; positive regulation of cardiac muscle cell proliferation; and thalamus development. Located in neuronal cell body and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study middle cerebral artery infarction. Biomarker of Alzheimer's disease; congestive heart failure; hypothyroidism; mental depression; and myocardial infarction. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic Cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncam1 基因产物(5)

mRNA Protein Name
NM_001395707.1 NP_001382636.1 neural cell adhesion molecule 1 isoform 1 precursor
NM_001395708.1 NP_001382637.1 neural cell adhesion molecule 1 isoform 2 precursor
NM_001395709.1 NP_001382638.1 neural cell adhesion molecule 1 isoform 3 precursor
NM_001395710.1 NP_001382639.1 neural cell adhesion molecule 1 isoform 4 precursor
NM_031521.3 NP_113709.1 neural cell adhesion molecule 1 isoform 5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables LRR domain binding IPI
IPI: 通过物理相互作用推断
15865439 RGD
enables phosphatase binding IDA
IDA: 通过直接分析推断
15865439 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15865439 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
16609270 RGD
involved in axonal fasciculation IMP
IMP: 通过突变表型推断
3856258 RGD
involved in behavioral response to ethanol IEP
IEP: 通过表达模式推断
16207289 RGD
involved in cellular response to ethanol IDA
IDA: 通过直接分析推断
10936176 RGD
involved in cellular response to ethanol IEP
IEP: 通过表达模式推断
16207289 RGD
involved in cellular response to fluoride IEP
IEP: 通过表达模式推断
17537562 RGD
involved in cellular response to molecule of bacterial origin IEP
IEP: 通过表达模式推断
19853610 RGD
involved in learning or memory IDA
IDA: 通过直接分析推断
18702715 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
18194217 RGD
involved in medium-term memory IEP
IEP: 通过表达模式推断
16207289 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
7997264 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
7997264 RGD
involved in multicellular organismal response to stress IDA
IDA: 通过直接分析推断
17429411 RGD
involved in negative regulation of programmed cell death IMP
IMP: 通过突变表型推断
18757519 RGD
involved in neuron development IDA
IDA: 通过直接分析推断
16958105 RGD
involved in peripheral nervous system axon regeneration IEP
IEP: 通过表达模式推断
15679872 RGD
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
19853610 RGD
involved in regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
26821693 RGD
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24399412 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
12499861 RGD
involved in response to cocaine IDA
IDA: 通过直接分析推断
16081054 RGD
involved in response to lead ion IDA
IDA: 通过直接分析推断
18499259 RGD
involved in response to morphine IEP
IEP: 通过表达模式推断
15673448 RGD
involved in response to oxidative stress IEP
IEP: 通过表达模式推断
16207289 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
17307340 RGD
involved in thalamus development IDA
IDA: 通过直接分析推断
17292800 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
7997264 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
7997264 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
10936176 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
2592994 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16216431 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
2592994 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
2592994 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neural cell adhesion molecule 1

重组 Ncam1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73749 NCAM-1/CD56 Protein, Rat (HEK293, His) P13596 (L20-T721) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99372 Lorvotuzumab 99.77% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09063 NCAM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncam1 NCBI NCBI:4684
Macaca fascicularis Ncam1 NCBI NCBI:102144192
Mus musculus Ncam1 NCBI NCBI:17967
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