2. Gene
  3. Pim1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

Pim1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Pim-1 原癌基因， 丝氨酸/苏氨酸激酶

种属: Rattus norvegicus

基因 ID: 24649 | 基因类型: protein coding

关于 Pim1

Primary_assembly 20: 7,554,921-7,559,174 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 245 orthologues, 2 paralogues and is associated with 9 phenotypes. Biased expression in Spleen (RPKM 162.5), Thymus (RPKM 157.5) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动；锰离子结合活性；和核糖体小亚基结合活性。预计参与多个过程，包括棕色脂肪细胞分化的正调节；细胞群增殖的正向调节；和转录调控，DNA 模板化。预测位于胞质溶胶中；核仁;和质膜。预计在细胞质中有活性。与人 PIM1 同源（Pim-1 原癌基因，丝氨酸/苏氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; manganese ion binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including positive regulation of brown fat cell differentiation; positive regulation of cell population proliferation; and regulation of transcription, DNA-templated. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim1 基因产物(1)

mRNA Protein Name
NM_017034.1 NP_058730.1 serine/threonine-protein kinase pim-1

Pim1 蛋白结构

STKc_PIM1

STKc_PIM1: cd14100 (36 - 289)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase pim-1

non-specific serine/threonine protein kinase

pim-1 oncogene

proto-oncogene serine/threonine-protein kinase Pim-1

proviral integration site 1

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
生物活性分子 (29)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10371 Pim1/AKK1-IN-1 Inhibitor 98.20% 否
HY-N4149 Quercetagetin Inhibitor 99.94% 否
HY-16576A SMI-4a Inhibitor 99.63% 否
HY-16976 GDC-0339 Inhibitor 99.87% 否
HY-101947 SMI-16a Inhibitor ≥98.0% 否
HY-135906 CK2/ERK8-IN-1 Inhibitor ≥99.0% 否
HY-120758 SEL24-B489 Inhibitor 99.02% 否
HY-18086 TCS PIM-1 1 Inhibitor 98.01% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-108605 PIM1-IN-2 Inhibitor ≥99.0% 否
HY-164460 AZD1897 Inhibitor / 否
HY-101870 Uzansertib Inhibitor / 否
HY-149054 GSK-3β inhibitor 13 Inhibitor / 否
HY-168071 Pim-1 kinase inhibitor 11 Inhibitor / 否
HY-168517 PIM-1/CK2-IN-2 Inhibitor / 否
HY-135816 CK2/PIM1-IN-1 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / 否
HY-143897 PIM1-IN-3 Inhibitor / 否
HY-156470 Multi-kinase-IN-6 Inhibitor / 否
HY-147921 PIM1-IN-7 Inhibitor / 否
HY-150731 Pim-1 kinase inhibitor 3 Inhibitor / 否
HY-147920 PIM1-IN-6 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-123983 HS56 Inhibitor / 否
HY-143898 PIM1-IN-4 Inhibitor / 否
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / 否
HY-101783 GNE-955 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pim1 NCBI NCBI:5292
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