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  3. ALPI - alkaline phosphatase, intestinal Gene

ALPI - alkaline phosphatase, intestinal Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：碱性磷酸酶，肠道

种属: Homo sapiens

同用名: IAP

基因 ID: 248 | 基因类型: protein coding

关于 ALPI

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,456,153-232,460,753 (from NCBI)

This gene has 2 transcripts (splice variants), 362 orthologues and 3 paralogues. Biased expression in duodenum (RPKM 85.5), small intestine (RPKM 83.4) and 1 other tissue.

功能概要

至少有四种不同但相关的碱性磷酸酶：肠、胎盘、胎盘样和肝/骨/肾 (组织非特异性) 。肠道碱性磷酸酶基因编码一种消化刷状缘酶。这种酶是肠粘膜防御系统的一个组成部分，被认为在脂多糖解毒和预防肠道细菌移位方面发挥作用。[RefSeq 提供，2014 年 12 月]

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal Alkaline Phosphatase gene encodes a digestive brush-border Enzyme. This Enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of Bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

ALPI 基因产物(1)

mRNA Protein Name
NM_001631.5 NP_001622.2 intestinal-type alkaline phosphatase precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protease binding IPI
IPI: 通过物理相互作用推断
18307834 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALPI 蛋白结构

Alk_phosphatase

Alk_phosphatase: Alkaline phosphatase (52 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 528 a.a.
蛋白主名 其他名称

intestinal-type alkaline phosphatase

Kasahara isozyme

ALPI 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ALPI P09923 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
种属内
ALPI P09923 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
种属内
ALPI P09923 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ALPI 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71692 ALPI Protein, Human (His) P09923 (26E-500C) ≥95%
HY-P72822 ALPI Protein, Human (HEK293, His) P09923 (V20-D503) ≥95%
HY-P72821 ALPI Protein, Human (HEK293, Fc) P09923 (M1-D503) ≥95%
HY-P700394 ALPI Protein, Human (HEK293, N-His) P09923 (V20-D503) ≥95%

关联疾病

疾病名称 别名
Hypophosphatasia

Phosphoethanolaminuria

Childhood Hypophosphatasia

Deficiency Of Alkaline Phosphatase

Hypophospatasia, Childhood

Hypophosphatasia Mild

Phosphoethanol-Aminuria

Rathburn Disease

Hpp

Rathbun Disease

Hypophosphatasia, Childhood

Infantile Hypophosphatasia
Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea
Tracheal Cancer

Tracheal Carcinoma

Malignant Neoplasm Of Trachea

Tracheal Neoplasms

Pancoast Tumor

Pulmonary Sulcus Neoplasm

Pancoast Syndrome
Trachea Carcinoma

Pancoast Tumor

Carcinoma Of The Trachea

Pancoast'S Tumor

Malignant Superior Sulcus Tumor

Malignant Superior Sulcus Tumour

Pancoast Tumour

Pancoast'S Syndrome

Pancoast'S Tumour

Pulmonary Sulcus Tumor

Pulmonary Sulcus Tumour

Superior Pulmonary Sulcus Syndrome

Pancoast Syndrome
Testis Seminoma

Seminoma Of Testis

Seminoma Testis

Testicular Seminoma Pure

Seminoma
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00628 ALPI Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ALPI RGD RGD:2099
Macaca mulatta ALPI VGNC VGNC:69800
Mus musculus ALPI NCBI NCBI:76768
Others ALPI NCBI
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