Esr1 - estrogen receptor 1 Gene

中文名称：雌激素受体 1

种属: Rattus norvegicus

同用名: Esr; ER-alpha; RNESTROR

关于 Esr1

功能概要

该基因编码的蛋白可启动多种功能，包括磷脂酰肌醇 3-激酶调节亚基结合活性；启动子特异性染色质结合活性；和转录辅激活因子结合活性。参与多个过程，包括细胞对脂质的反应；调节神经元死亡；和生殖结构发育。位于多个细胞成分中，包括 T 管；核周;和细胞质的核周区。部分含蛋白质复合物。用于研究多种疾病，包括帕金森病；不孕症;肥胖;胸膜炎;和前列腺疾病（多种）。隐睾生物标志物；骨质疏松症；和卵巢癌。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；骨病（多发）；乳腺癌（多发性）； 2型糖尿病；和白癜风。与人类 ESR1（雌激素受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian Cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast Cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (Estrogen Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]