2. Gene
  3. Myo5b - myosin Vb Gene

Myo5b - myosin Vb Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Myr6

基因 ID: 25132 | 基因类型: protein coding

关于 Myo5b

功能概要

Enables several functions, including ATP hydrolysis activity; ionotropic glutamate receptor binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to glycine; generation of neurons; and positive regulation of exosomal secretion. Located in dendritic spine; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic recycling endosome membrane. Colocalizes with recycling endosome. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Orthologous to human MYO5B (Myosin VB). [provided by Alliance of Genome Resources, Apr 2022]

Myo5b 基因产物(1)

mRNA Protein Name
NM_017083.2 NP_058779.2 unconventional myosin-Vb
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
18984164 RGD
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
16338934 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16338934 RGD
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
23770993 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glycine IEP
IEP: 通过表达模式推断
18984164 RGD
involved in dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
18984164 RGD
involved in neurotransmitter receptor transport, endosome to plasma membrane IDA
IDA: 通过直接分析推断
18984164 RGD
involved in neurotransmitter receptor transport, endosome to plasma membrane IMP
IMP: 通过突变表型推断
18984164 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
23770993 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
23554492 RGD
involved in positive regulation of exosomal secretion IMP
IMP: 通过突变表型推断
18984164 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
19542231 RGD
involved in regulation of modification of postsynaptic structure IDA
IDA: 通过直接分析推断
18984164 RGD
involved in regulation of modification of postsynaptic structure IMP
IMP: 通过突变表型推断
18984164 RGD
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
18701652 RGD
involved in synaptic vesicle recycling via endosome IDA
IDA: 通过直接分析推断
18984164 RGD
involved in synaptic vesicle recycling via endosome IMP
IMP: 通过突变表型推断
18984164 RGD
involved in vesicle-mediated transport in synapse IDA
IDA: 通过直接分析推断
18984164 RGD
involved in vesicle-mediated transport in synapse IMP
IMP: 通过突变表型推断
18984164 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
18984164 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
18984164 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
16338934 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18984164 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
18984164 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16338934 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16338934 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
18984164 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
18984164 RGD
is active in postsynaptic recycling endosome membrane IDA
IDA: 通过直接分析推断
18984164 RGD
is active in postsynaptic recycling endosome membrane IMP
IMP: 通过突变表型推断
18984164 RGD
located in recycling endosome IDA
IDA: 通过直接分析推断
18984164 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

unconventional myosin-Vb

Myosin of the dilute-myosin-V family

myosin 5B

myosin heavy chain myr 6

Myo5b 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Myo5b P70569 Gria1 Rattus norvegicus P19490
Anti Bait CoIP
16338934
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08947 MYO5B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Myo5b NCBI NCBI:4645
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