Gria1 - glutamate ionotropic receptor AMPA type subunit 1 Gene

种属: Rattus norvegicus

同用名: GluA1; gluR-A

基因 ID: 50592 | 基因类型: protein coding

关于 Gria1

功能概要

Enables several functions, including AMPA glutamate receptor activity; Enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; long-term memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Used to study hyperhomocysteinemia. Biomarker of epilepsy; hepatic encephalopathy; status epilepticus; and visual epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Gria1 基因产物(1)

mRNA	Protein	Name
NM_031608.2	NP_113796.1	glutamate receptor 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables AMPA glutamate receptor activity	IDA IDA: 通过直接分析推断	19265014	RGD
enables G-protein alpha-subunit binding	IPI IPI: 通过物理相互作用推断	19942860	RGD
enables G-protein beta-subunit binding	IDA IDA: 通过直接分析推断	19942860	RGD
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	16634638	RGD
enables adenylate cyclase binding	IDA IDA: 通过直接分析推断	19942860	RGD
enables amyloid-beta binding	IPI IPI: 通过物理相互作用推断	20032460	RGD
enables beta-2 adrenergic receptor binding	IPI IPI: 通过物理相互作用推断	19942860	RGD
enables glutamate receptor binding	IPI IPI: 通过物理相互作用推断	21639859	RGD
enables glutamate-gated calcium ion channel activity	IDA IDA: 通过直接分析推断	1709304	RGD
enables glutamate-gated receptor activity	IDA IDA: 通过直接分析推断	1699275	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19461580	RGD
enables immunoglobulin binding	IPI IPI: 通过物理相互作用推断	26595655	RGD
enables ionotropic glutamate receptor binding	IPI IPI: 通过物理相互作用推断	10414981	RGD
enables myosin V binding	IPI IPI: 通过物理相互作用推断	16338934	RGD
enables peptide hormone receptor binding	IPI IPI: 通过物理相互作用推断	25539504	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	9677374	RGD
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	17194442	RGD
enables protein kinase A binding	IDA IDA: 通过直接分析推断	19942860	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	17329210	RGD
enables scaffold protein binding	IPI IPI: 通过物理相互作用推断	10939335	RGD
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	17194442	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: 通过直接分析推断	10731148	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: 通过突变表型推断	10731148	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in behavioral response to pain	IEP IEP: 通过表达模式推断	25716866	RGD
involved in cellular response to L-glutamate	IEP IEP: 通过表达模式推断	12390532	RGD
involved in cellular response to amine stimulus	IEP IEP: 通过表达模式推断	19674091	RGD
involved in cellular response to amino acid stimulus	IEP IEP: 通过表达模式推断	19913087	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IDA IDA: 通过直接分析推断	14597197	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: 通过表达模式推断	24712995	RGD
involved in cellular response to dsRNA	IEP IEP: 通过表达模式推断	19958814	RGD
involved in cellular response to growth factor stimulus	IEP IEP: 通过表达模式推断	19958814	RGD
involved in cellular response to organic cyclic compound	IEP IEP: 通过表达模式推断	20025928	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: 通过表达模式推断	20237279	RGD
involved in cerebral cortex development	IEP IEP: 通过表达模式推断	14597197	RGD
involved in conditioned place preference	IMP IMP: 通过突变表型推断	23345231	RGD
involved in long-term memory	IMP IMP: 通过突变表型推断	19547753	RGD
involved in long-term synaptic potentiation	IEP IEP: 通过表达模式推断	26088419	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	11348590	RGD
involved in neuronal action potential	IMP IMP: 通过突变表型推断	12536214	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	23345231	RGD
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	23460828	RGD
involved in positive regulation of locomotion involved in locomotory behavior	IMP IMP: 通过突变表型推断	21613507	RGD
involved in positive regulation of membrane potential	IMP IMP: 通过突变表型推断	20165912	RGD
involved in positive regulation of synaptic transmission	IMP IMP: 通过突变表型推断	11348590	RGD
involved in receptor internalization	IDA IDA: 通过直接分析推断	11100149	RGD
involved in regulation of monoatomic ion transmembrane transport	IMP IMP: 通过突变表型推断	21613507	RGD
involved in regulation of receptor recycling	IMP IMP: 通过突变表型推断	11348590	RGD
involved in regulation of synaptic plasticity	IMP IMP: 通过突变表型推断	12536214	RGD
involved in response to arsenic-containing substance	IEP IEP: 通过表达模式推断	19761793	RGD
involved in response to cocaine	IEP IEP: 通过表达模式推断	15548228	RGD
involved in response to electrical stimulus	IEP IEP: 通过表达模式推断	20554014	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	19596275	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	21041654	RGD
involved in response to fungicide	IEP IEP: 通过表达模式推断	19591855	RGD
involved in response to lithium ion	IEP IEP: 通过表达模式推断	15269270	RGD
involved in response to morphine	IEP IEP: 通过表达模式推断	24201449	RGD
involved in response to morphine	IMP IMP: 通过突变表型推断	22072679	RGD
involved in response to nutrient levels	IDA IDA: 通过直接分析推断	21425350	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	19940171	RGD
involved in response to peptide hormone	IEP IEP: 通过表达模式推断	20554878	RGD
involved in response to psychosocial stress	IEP IEP: 通过表达模式推断	32594591	RGD
involved in response to sucrose	IDA IDA: 通过直接分析推断	21425350	RGD
involved in response to toxic substance	IMP IMP: 通过突变表型推断	20165912	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	19940171	RGD
involved in spinal cord development	IEP IEP: 通过表达模式推断	19446017	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of AMPA glutamate receptor complex	IDA IDA: 通过直接分析推断	19265014	RGD
located in asymmetric synapse	IDA IDA: 通过直接分析推断	12077196	RGD
located in cell surface	IDA IDA: 通过直接分析推断	19321442	RGD
located in cell-cell junction	IDA IDA: 通过直接分析推断	26595655	RGD
located in cytosol	IDA IDA: 通过直接分析推断	34742997	RGD
located in dendrite	IDA IDA: 通过直接分析推断	12629171	RGD
located in dendrite membrane	IDA IDA: 通过直接分析推断	11931740	RGD
located in dendritic shaft	IDA IDA: 通过直接分析推断	11100149	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	12077196	RGD
located in early endosome	IDA IDA: 通过直接分析推断	11100149	RGD
located in early endosome membrane	IDA IDA: 通过直接分析推断	15456832	RGD
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	15456832	RGD
located in excitatory synapse	IDA IDA: 通过直接分析推断	19730411	RGD
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	12390532	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	10731148	RGD
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	10731148	RGD
located in neuromuscular junction	IDA IDA: 通过直接分析推断	19918122	RGD
located in neuron projection	IDA IDA: 通过直接分析推断	12390532	RGD
located in neuron spine	IDA IDA: 通过直接分析推断	10985351	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	11100149	RGD
located in neuronal cell body membrane	IDA IDA: 通过直接分析推断	10985351	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	27881773	RGD
located in postsynaptic density	IDA IDA: 通过直接分析推断	19077125	RGD
is active in postsynaptic density membrane	IDA IDA: 通过直接分析推断	15610164	RGD
located in postsynaptic density, intracellular component	IDA IDA: 通过直接分析推断	26088419	RGD
is active in postsynaptic membrane	IDA IDA: 通过直接分析推断	16903873	RGD
is active in presynaptic active zone membrane	IDA IDA: 通过直接分析推断	15610164	RGD
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	16903873	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	17329210	RGD
located in proximal dendrite	IDA IDA: 通过直接分析推断	23844251	RGD
located in recycling endosome membrane	IDA IDA: 通过直接分析推断	15456832	RGD
located in synapse	IDA IDA: 通过直接分析推断	10939335	RGD
located in synapse	IMP IMP: 通过突变表型推断	12536214	RGD
located in synaptic membrane	IDA IDA: 通过直接分析推断	10414981	RGD
located in synaptic membrane	IMP IMP: 通过突变表型推断	27307232	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

glutamate receptor 1

AMPA-selective glutamate receptor 1	GluR1
gluR-1	gluR-K1
glutamate receptor A	glutamate receptor subunit GluR1
glutamate receptor, ionotropic, AMPA 1	glutamate receptor, ionotropic, AMPA1 (alpha 1)

Gria1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Gria1	P19490	Arhgef2	Rattus norvegicus	Q5FVC2	Anti Bait CoIP	19208802
种属内	Gria1	P19490	Cnih2	Rattus norvegicus	Q5BJU5	Anti Tag CoIP	20805473
种属内	Gria1	P19490	Cnih2	Rattus norvegicus	Q5BJU5	Anti Bait CoIP	20805473
种属内	Gria1	P19490	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	19942860
种属内	Gria1	P19490	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	16338934
种属内	Gria1	P19490	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	19942860
种属内	Gria1	P19490	Cacng2	Rattus norvegicus	Q71RJ2	Anti Bait CoIP	20805473
种属内	Gria1	P19490	Cacng2	Rattus norvegicus	Q71RJ2	Anti Bait CoIP	19208802
种属内	Gria1	P19490	Gria2	Rattus norvegicus	P19491	Solution Sedimentation	21317873
种属内	Gria1	P19490	Dlg4	Rattus norvegicus	P31016	Competition Binding	19942860
种属内	Gria1	P19490	Cacng2	Rattus norvegicus	Q71RJ2	Anti Tag CoIP	20805473
种属内	Gria1	P19490	Gria1	Rattus norvegicus	P19490	Solution Sedimentation	21317873
种属内	Gria1	P19490	Cacng2	Rattus norvegicus	Q71RJ2	Anti Tag CoIP	21376300
种属内	Gria1	P19490	Gria1	Rattus norvegicus	P19490	Solution Sedimentation	19461580
种属内	Gria1	P19490	Adrb2	Rattus norvegicus	P10608	Anti Bait CoIP	19942860
种属内	Gria1	P19490	Myo5b	Rattus norvegicus	P70569	Anti Bait CoIP	16338934

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05791	GRIA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Gria1	NCBI	NCBI:2890

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