2. Gene
  3. Chrna4 - cholinergic receptor nicotinic alpha 4 subunit Gene

Chrna4 - cholinergic receptor nicotinic alpha 4 subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: NARAC

基因 ID: 25590 | 基因类型: protein coding

关于 Chrna4

功能概要

Enables acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and quaternary ammonium group binding activity. Contributes to heterocyclic compound binding activity. Involved in cholinergic synaptic transmission; regulation of acetylcholine-gated cation channel activity; and response to acetylcholine. Located in dendrite; membrane; and neuronal cell body. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna4 基因产物(1)

mRNA Protein Name
NM_024354.2 NP_077330.2 neuronal acetylcholine receptor subunit alpha-4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine binding IDA
IDA: 通过直接分析推断
9030613 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: 通过直接分析推断
12202488 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: 通过突变表型推断
11259617 RGD
contributes to heterocyclic compound binding IDA
IDA: 通过直接分析推断
22550286 RGD
enables heterocyclic compound binding IDA
IDA: 通过直接分析推断
15016836 RGD
contributes to heterocyclic compound binding IPI
IPI: 通过物理相互作用推断
16129735 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12202488 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
20796176 RGD
enables quaternary ammonium group binding IDA
IDA: 通过直接分析推断
15016836 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: 通过实验结果推断
15044058 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: 通过直接分析推断
15044058 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of acetylcholine-gated cation channel activity IMP
IMP: 通过突变表型推断
11904236 RGD
involved in response to acetylcholine IDA
IDA: 通过直接分析推断
15016836 RGD
involved in synaptic transmission, cholinergic IMP
IMP: 通过突变表型推断
15026122 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of acetylcholine-gated channel complex IDA
IDA: 通过直接分析推断
9030613 RGD
is active in cholinergic synapse EXP
EXP: 通过实验结果推断
15044058 RGD
is active in cholinergic synapse IDA
IDA: 通过直接分析推断
10414976 RGD
located in dendrite IDA
IDA: 通过直接分析推断
11297818 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
11297818 RGD
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
10414976 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
24607281 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
16129735 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuronal acetylcholine receptor subunit alpha-4

Neuronal nicotinic acetylcholine receptor alpha 4 subunit

cholinergic receptor, nicotinic, alpha 4 (neuronal)

cholinergic receptor, nicotinic, alpha polypeptide 4

Chrna4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Chrna4 P09483 Chrna5 Rattus norvegicus P20420
Density Sedimentation
20566638
种属内
Chrna4 P09483 Chrna5 Rattus norvegicus P20420
BN-PAGE
20566638
种属内
Chrna4 P09483 Chrnb2 Rattus norvegicus P12390
Density Sedimentation
20566638
种属内
Chrna4 P09483 Chrnb2 Rattus norvegicus P12390
BN-PAGE
20566638
种属内
Chrna4 P09483 Chrnb4 Rattus norvegicus P12392
BN-PAGE
20566638
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02669 CHRNA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chrna4 NCBI NCBI:1137
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