Hmgcr - 3-hydroxy-3-methylglutaryl-CoA reductase Gene

中文名称：3-羟基-3-甲基戊二酰辅酶 A 还原酶

种属: Rattus norvegicus

同用名: 3H3M

关于 Hmgcr

功能概要

实现相同的蛋白质结合活性和蛋白磷酸酶 2A 结合活性。参与多个过程，包括脂质稳态； MAPK 级联的正调控；和调节横纹肌细胞凋亡过程。位于细胞内膜界的细胞器中。用于研究威尔逊病；药物性肝炎；晚期肾脏疾病;肺动脉高压;和 2 型糖尿病。慢性肾病的生物标志物；非酒精性脂肪肝病；和提前绝经。该基因的人类直系同源物与多种疾病有关，包括哮喘；冠状动脉疾病（多发性）；失智;糖尿病（多发性）；和神经退行性疾病（多种）。与人 HMGCR（3-羟基-3-甲基戊二酰辅酶 A 还原酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and protein Phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Located in intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]