Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

中文名称：含核苷酸结合寡聚化结构域 2

种属: Mus musculus

同用名: CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik

关于 Nod2

功能概要

该基因编码的蛋白可启动胞壁酰二肽结合活性。参与多个过程，包括巨噬细胞凋亡过程的负调控；大分子代谢过程的正向调控；和前列腺素-E 合酶活性的正调节。作用于多个过程的上游或内部，包括细胞内信号转导的正向调节；基因表达的调节；和对细菌的反应。预计位于多个细胞成分中，包括高尔基体；基底外侧质膜；和吞噬泡。预测为质膜的锚定成分。预计是含蛋白质复合物的一部分。预计在胞质溶胶中有活性。用于研究炎症性肠病 1. 该基因的人类直向同源基因与多种疾病有关，包括 Blau 综合征；自身免疫性疾病（多种）；胃肠道癌；肠道疾病（多种）；和肺部疾病（多种）。与人 NOD2 同源（包含 2 的核苷酸结合寡聚化结构域）。 [由基因组资源联盟提供，2022 年 4 月]

Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of prostaglandin-E synthase activity. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]