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  3. MOB4 - MOB family member 4, phocein Gene

MOB4 - MOB family member 4, phocein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MOB 家族成员 4，phocein

种属: Homo sapiens

同用名: 2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3

基因 ID: 25843 | 基因类型: protein coding

关于 MOB4

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:197,515,554-197,553,699 (from NCBI)

This gene has 8 transcripts (splice variants), 234 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues.

功能概要

该基因是根据其与小鼠对应物的相似性来识别的。对小鼠对应物的研究表明，该基因的表达可能在合子基因激活后的卵母细胞成熟和植入前过程中受到调节。已经观察到编码不同亚型的可变剪接转录物变体。自然发生的通读转录发生在该基因座和相邻基因座 HSPE1 之间。[RefSeq 提供，2011 年 2 月]

This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

MOB4 基因产物(4)

mRNA Protein Name
NM_001100819.3 NP_001094289.1 MOB-like protein phocein isoform 3
NM_001204094.1 NP_001191023.1 MOB-like protein phocein isoform 2
NM_015387.5 NP_056202.2 MOB-like protein phocein isoform 1
NM_199482.4 NP_955776.1 MOB-like protein phocein isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
33633399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of hippo signaling IDA
IDA: 通过直接分析推断
33633399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FAR/SIN/STRIPAK complex IDA
IDA: 通过直接分析推断
18782753 GOA
located in Golgi apparatus IDA
IDA: 通过直接分析推断
11251078 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MOB4 蛋白结构

Mob1_phocein

Mob1_phocein: Mob1/phocein family (40 - 208)

  • 0
  • 100
  • 200
  • 225 a.a.
蛋白主名 其他名称

MOB-like protein phocein

MOB1, Mps One Binder kinase activator-like 3

MOB4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MOB4 Q9Y3A3 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
种属内
MOB4 Q9Y3A3 STRN Homo sapiens O43815
TAP
18782753
种属内
MOB4 Q9Y3A3 STRN3 Homo sapiens Q13033-2
Anti Tag CoIP
19156129
种属内
MOB4 Q9Y3A3 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
种属内
MOB4 Q9Y3A3 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
19156129
种属内
MOB4 Q9Y3A3 CTTNBP2NL Homo sapiens Q9P2B4
TAP
18782753
种属内
MOB4 Q9Y3A3 TRAF3IP3 Homo sapiens Q9Y228
Anti Tag CoIP
18782753
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MOB4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70940 MOB4 Protein, Human (His) Q9Y3A3 (M1-A225) ≥95%

关联疾病

疾病名称 别名
Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3
Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10

OI10

Osteogenesis Imperfecta Type X

Oi, Type X

Osteogenesis Imperfecta 10

Oi Type X

Oi-X
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08577 MOB4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MOB4 RGD RGD:620183
Mus musculus MOB4 MGD MGI:104899
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