1. Gene
  2. USP49 - ubiquitin specific peptidase 49 Gene

USP49 - ubiquitin specific peptidase 49 Gene

中文名称:泛素特异性肽酶 49

种属: Homo sapiens

基因 ID: 25862 | 基因类型: protein coding

关于 USP49

This gene has 6 transcripts (splice variants), 206 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 2.1), thyroid (RPKM 1.8) and 25 other tissues.

功能概要

启用半胱氨酸型内肽酶活性;组蛋白结合活性;和硫醇依赖性去泛素化酶。通过剪接体参与组蛋白 H2B 保守的 C 末端赖氨酸去泛素化和 mRNA 剪接。预测位于核质中。预计在细胞质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent Deubiquitinase. Involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

USP49 基因产物(3)

mRNA Protein Name
NM_001286554.2 NP_001273483.1 ubiquitin carboxyl-terminal hydrolase 49 isoform a
NM_001384542.1 NP_001371471.1 ubiquitin carboxyl-terminal hydrolase 49 isoform a
NM_018561.5 NP_061031.2 ubiquitin carboxyl-terminal hydrolase 49 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
14715245 GOA
enables cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
23824326 GOA
enables histone H2B deubiquitinase activity IDA
IDA: 通过直接分析推断
23824326 GOA
enables histone binding IDA
IDA: 通过直接分析推断
23824326 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19615732 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
23824326 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
28363942 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
28363942 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

USP49 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (26 - 87)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (252 - 654)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 49

deubiquitinating enzyme 49

直系同源

种属 基因名 来源 基因 ID
Canis familiaris USP49 VGNC VGNC:48200
Bos taurus USP49 VGNC VGNC:36734
Felis catus USP49 VGNC VGNC:66892
Mus musculus USP49 MGD MGI:2685391
Rattus norvegicus USP49 RGD RGD:1310513
Macaca mulatta USP49 VGNC VGNC:79231