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  2. TMEM98 - transmembrane protein 98 Gene

TMEM98 - transmembrane protein 98 Gene

中文名称:跨膜蛋白 98

种属: Homo sapiens

同用名: TADA1

基因 ID: 26022 | 基因类型: protein coding

关于 TMEM98

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,928,153-32,944,315 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 69.4), endometrium (RPKM 44.6) and 23 other tissues.

功能概要

该基因编码跨膜蛋白。该基因的错义突变导致 Nanophthalmos 4 (NNO4) 。已发现该基因编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供,2014 年 9 月]

This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

TMEM98 基因产物(3)

mRNA Protein Name
NM_001033504.2 NP_001028676.1 transmembrane protein 98
NM_001301746.2 NP_001288675.1 transmembrane protein 98
NM_015544.3 NP_056359.2 transmembrane protein 98
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular exosome IDA
IDA: 通过直接分析推断
25946230 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
25946230 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
25946230 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMEM98 蛋白结构

GCIP

GCIP: Grap2 and cyclin-D-interacting (79 - 161)

  • 0
  • 100
  • 200
  • 226 a.a.
蛋白主名 其他名称

transmembrane protein 98

TMEM98 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TMEM98 Q9Y2Y6 ATP1B3 Homo sapiens P54709
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 ATP1B3 Homo sapiens P54709
Y2H Prey Pooling
32296183
Intra TMEM98 Q9Y2Y6 STOM Homo sapiens P27105
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra TMEM98 Q9Y2Y6 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra TMEM98 Q9Y2Y6 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra TMEM98 Q9Y2Y6 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra TMEM98 Q9Y2Y6 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra TMEM98 Q9Y2Y6 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra TMEM98 Q9Y2Y6 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nanophthalmos 4

NNO4

Nanophthalmia 4

Nanophthalmos, Type 4

Nanophthalmos

Nanophthalmia

Aqueous Misdirection
Interval Angle-Closure Glaucoma

Intermittent Angle-Closure Glaucoma

Angle-Closure Glaucoma, Subacute

Prodromal Angle Closure Glaucoma

Microphthalmia, Isolated 6

Isolated Microphthalmia 6

MCOP6

Microphthalmia, Posterior Nonsyndromic

Posterior Nonsyndromic Microphthalmia

Microphthalmia, Isolated, 6

Autosomal Recessive Posterior Microphthalmos

Posterior Non-Syndromic Microphthalmia

Microphthalmia, Isolated, Type 6

Farsightedness

Hypermetropia

Hyperopia

Far-Sightedness

Farsighted

Long-Sighted

Long-Sightedness

Bullous Retinoschisis
Kenny-Caffey Syndrome

Kenny Syndrome

Optic Disk Drusen

Optic Disc Drusen

Drusen Of Optic Disc

Optic Nerve Head Drusen

Drusen Optic Disc

Kenny-Caffey Syndrome, Type 2

KCS2

Kenny-Caffey Syndrome Type 2

Autosomal Dominant Kenny-Caffey Syndrome

Kenny Syndrome

Dwarfism, Cortical Thickening Of Tubular Bones, And Transient Hypocalcemia

Dwarfism, Cortical Thickening Of Tubular Bones And Transient Hypocalcemia

Kenny-Caffey Syndrome, Autosomal Dominant

Kenny-Caffey Syndrome 2

Dwarfism With Cortical Thickening Of Tubular Bones And Transient Hypocalcemia

Kenny-Caffey Syndrome

Isolated Microphthalmia
Vitreoretinochoroidopathy

Autosomal Dominant Vitreoretinochoroidopathy

Advirc

Vitreoretinochoroidopathy With Microcornea, Glaucoma, And Cataract

Vitreoretinochoroidopathy, Autosomal Dominant, With Nanophthalmos

Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 2

Vitreoretinochoroidopathy Dominant

VRCP

Vitreoretinochoroidopathy, Autosomal Dominant

Vrcp Autosomal Dominant

Vitreoretinochoroidopathy Autosomal Dominant With Nanophthalmos, Microcornea, Rod-Cone Dystrophy, Cataract And Posterior Staphyloma

Vitreoretinochoroidopathy With Microcornea-Glaucoma-Cataract

Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Total Anomalous Pulmonary Venous Return 1

Scimitar Syndrome

Total Anomalous Pulmonary Venous Return

Anomalous Pulmonary Venous Return

Scimitar Anomaly

TAPVR1

Apvr

Halasz Syndrome

Hypogenetic Lung Syndrome

Pulmonary Venolobar Syndrome

TAPVR

Congenital Total Pulmonary Venous Return Anomaly

Congenital Venolobar Syndrome

Mirror-Image Lung Syndrome

Vena Cava Bronchovascular Syndrome

Pulmonary Venous Return Anomaly

Congenital Pulmonary Venolobar Syndrome

Epibronchial Right Pulmonary Vein Syndrome

Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm

Primary Angle-Closure Glaucoma

Primary Angle Closure Glaucoma

Angle Closure Glaucoma

Acg - [Angle Closure Glaucoma]

Angle-Closure Glaucoma

Closed Angle Glaucoma

Acute Glaucoma

Prodromal Angle Closure Glaucoma

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

Refractive Error

Refractive Errors

Fundus Albipunctatus

Retinitis Punctata Albescens

Pigmentary Retinal Dystrophy

RPA

Albipunctate Retinal Dystrophy

Lauber'S Disease

FALBI

Fa

Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TMEM98 RGD RGD:1359736
Felis catus TMEM98 VGNC VGNC:66374
Macaca mulatta TMEM98 VGNC VGNC:99306
Mus musculus TMEM98 MGD MGI:1923457
Bos taurus TMEM98 VGNC VGNC:36130
Canis familiaris TMEM98 VGNC VGNC:47618