WIPI2 - WD repeat domain, phosphoinositide interacting 2 Gene

中文名称：WD 重复结构域，磷酸肌醇相互作用 2

种属: Homo sapiens

同用名: Atg21; ATG18B; CGI-50; IDDSSA; WIPI-2

基因 ID: 26100 | 基因类型: protein coding

关于 WIPI2

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,190,233-5,233,855 (from NCBI)

This gene has 14 transcripts (splice variants), 223 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 20.8), brain (RPKM 12.7) and 25 other tissues.

功能概要

WD40 重复蛋白是许多基本生物学功能的关键组成部分。他们通过提供用于同步和可逆蛋白质-蛋白质相互作用的 β-螺旋桨平台来调节多蛋白复合物的组装。 WD40 重复蛋白的 WIPI 亚家族成员，例如 WIPI2，具有 7 叶螺旋桨结构，并包含与磷脂相互作用的保守基序 (Proikas-Cezanne 等人，2004 [PubMed 15602573]) 。[OMIM 提供， 2008 年 3 月]

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with Phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

WIPI2 基因产物(6)

mRNA	Protein	Name
NM_001033518.2	NP_001028690.1	WD repeat domain phosphoinositide-interacting protein 2 isoform c
NM_001033519.2	NP_001028691.1	WD repeat domain phosphoinositide-interacting protein 2 isoform d
NM_001033520.1	NP_001028692.1	WD repeat domain phosphoinositide-interacting protein 2 isoform e
NM_001278299.2	NP_001265228.1	WD repeat domain phosphoinositide-interacting protein 2 isoform f
NM_015610.4	NP_056425.1	WD repeat domain phosphoinositide-interacting protein 2 isoform a
NM_016003.4	NP_057087.2	WD repeat domain phosphoinositide-interacting protein 2 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: 通过直接分析推断	20505359	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: 通过直接分析推断	20505359	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: 通过直接分析推断	25578879	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome assembly	IDA IDA: 通过直接分析推断	28890335	GOA
involved in autophagosome assembly	IMP IMP: 通过突变表型推断	20505359	GOA
NOT involved in autophagosome maturation	IMP IMP: 通过突变表型推断	20505359	GOA
involved in cellular response to starvation	IDA IDA: 通过直接分析推断	28561066	GOA
involved in protein localization to phagophore assembly site	IMP IMP: 通过突变表型推断	28561066	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
NOT colocalizes with autophagosome	IDA IDA: 通过直接分析推断	20505359	GOA
located in cytosol	IDA IDA: 通过直接分析推断	20505359	GOA
colocalizes with membrane	IDA IDA: 通过直接分析推断	25578879	GOA
located in phagophore assembly site	IDA IDA: 通过直接分析推断	22456507	GOA
located in phagophore assembly site membrane	IDA IDA: 通过直接分析推断	20505359	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WIPI2 蛋白结构

WD40

0
100
200
300
400
454 a.a.

蛋白主名

其他名称

WD repeat domain phosphoinositide-interacting protein 2

WD40 repeat protein interacting with phosphoinositides 2

WIPI2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WIPI2	Q9Y4P8	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
种属内	WIPI2	Q9Y4P8	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
种属内	WIPI2	Q9Y4P8	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
种属内	WIPI2	Q9Y4P8	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder With Short Stature And Variable Skeletal Anomalies

IDDSSA

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Neurodegeneration With Brain Iron Accumulation 5

NBIA5	Beta-Propeller Protein-Associated Neurodegeneration
Bpan	Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood
Senda	Neurodegeneration With Brain Iron Accumulation Type 5
Neurodegeneration With Brain Iron Accululation 5	Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood
Neurodegeneration, With Brain Iron Accululation, Type 5

Intracranial Arteriosclerosis

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15820	WIPI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	WIPI2	VGNC	VGNC:36943
Rattus norvegicus	WIPI2	RGD	RGD:1359154
Felis catus	WIPI2	VGNC	VGNC:67075
Macaca mulatta	WIPI2	VGNC	VGNC:79918
Mus musculus	WIPI2	MGD	MGI:1923831
Canis familiaris	WIPI2	VGNC	VGNC:48413

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WIPI2 - WD repeat domain, phosphoinositide interacting 2 Gene

关于 WIPI2

功能概要

WIPI2 基因产物(6)

WIPI2 蛋白结构

WIPI2 蛋白互作信息

关联疾病

直系同源

热门区域

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WIPI2 - WD repeat domain, phosphoinositide interacting 2 Gene

关于 WIPI2

功能概要

WIPI2 基因产物(6)

WIPI2 蛋白结构

WIPI2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z