GNL3 - G protein nucleolar 3 Gene

中文名称：G 蛋白核仁 3

种属: Homo sapiens

同用名: NS; E2IG3; NNP47; C77032

基因 ID: 26354 | 基因类型: protein coding

关于 GNL3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,685,920-52,694,497 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 6 paralogues. Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues.

功能概要

该基因编码的蛋白质可能与 p53 相互作用，并可能参与肿瘤发生。编码的蛋白质似乎对干细胞增殖也很重要。这种蛋白质存在于细胞核和核仁中。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2010 年 11 月]

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GNL3 基因产物(3)

mRNA	Protein	Name
NM_014366.5	NP_055181.3	guanine nucleotide-binding protein-like 3 isoform 1
NM_206825.2	NP_996561.1	guanine nucleotide-binding protein-like 3 isoform 2
NM_206826.1	NP_996562.1	guanine nucleotide-binding protein-like 3 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mRNA 5'-UTR binding	IDA IDA: 通过直接分析推断	16213212	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16097049	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of miRNA transcription	IMP IMP: 通过突变表型推断	25569094	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IMP IMP: 通过突变表型推断	22641345	GOA
involved in positive regulation of protein sumoylation	IMP IMP: 通过突变表型推断	22641345	GOA
involved in positive regulation of telomere maintenance	IMP IMP: 通过突变表型推断	22641345	GOA
involved in stem cell division	IDA IDA: 通过直接分析推断	25522312	GOA
involved in stem cell population maintenance	IMP IMP: 通过突变表型推断	25522312	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleolus	IDA IDA: 通过直接分析推断	22641345	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNL3 蛋白结构

GN3L_Grn1

MMR_HSR1

0
100
200
300
400
500
549 a.a.

蛋白主名

其他名称

guanine nucleotide-binding protein-like 3

E2-induced gene 3 protein

GNL3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GNL3	Q9BVP2	TERT	Homo sapiens	O14746	IF	24550003
种属内	GNL3	Q9BVP2	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	24550003
种属内	GNL3	Q9BVP2	PPP2R5A	Homo sapiens	Q15172	Y2H	16097049
种属内	GNL3	Q9BVP2	CEP19	Homo sapiens	Q96LK0	Y2H Array	32296183
种属内	GNL3	Q9BVP2	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	32296183
种属内	GNL3	Q9BVP2	NLE1	Homo sapiens	Q9NVX2	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

GNL3 抗体

目录号	产品名	应用	反应物种
HY-P82173	Nucleostemin Antibody (YA1918)	WB, ICC/IF, FC	Human

关联疾病

疾病名称

别名

Tibial Adamantinoma

Tibial Adamantinoma Morphology

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05566	GNL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05567	GNL3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	GNL3	VGNC	VGNC:73038
Canis familiaris	GNL3	VGNC	VGNC:41327
Rattus norvegicus	GNL3	RGD	RGD:631354
Felis catus	GNL3	VGNC	VGNC:62626
Bos taurus	GNL3	VGNC	VGNC:29473
Mus musculus	GNL3	MGD	MGI:1353651

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GNL3 - G protein nucleolar 3 Gene

关于 GNL3

功能概要

GNL3 基因产物(3)

GNL3 蛋白结构

GNL3 蛋白互作信息

GNL3 抗体

关联疾病

直系同源

热门区域

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GNL3 - G protein nucleolar 3 Gene

关于 GNL3

功能概要

GNL3 基因产物(3)

GNL3 蛋白结构

GNL3 蛋白互作信息

GNL3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z