GCKR - glucokinase regulator Gene

中文名称：葡萄糖激酶调节因子

种属: Homo sapiens

同用名: GKRP; FGQTL5

基因 ID: 2646 | 基因类型: protein coding

关于 GCKR

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,496,839-27,523,684 (from NCBI)

This gene has 6 transcripts (splice variants), 141 orthologues and is associated with 1 phenotype. Biased expression in liver (RPKM 19.0), stomach (RPKM 3.8) and 3 other tissues.

功能概要

该基因编码的蛋白质属于 SIS (糖异构酶) 蛋白质家族的 GCKR 亚家族。该基因产物是一种调节蛋白，通过非共价结合与酶形成无活性复合物来抑制肝脏和胰岛细胞中的葡萄糖激酶。该基因被认为是一种青年发病型糖尿病 (MODY) 的易感基因候选者。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits Glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the Enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]

GCKR 基因产物(1)

mRNA	Protein	Name
NM_001486.4	NP_001477.2	glucokinase regulatory protein

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables fructose-6-phosphate binding	IDA IDA: 通过直接分析推断	14627435	GOA
enables glucose sensor activity	IDA IDA: 通过直接分析推断	14627435	GOA
enables kinase inhibitor activity	IDA IDA: 通过直接分析推断	14627435	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11522786	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of glucokinase activity	IDA IDA: 通过直接分析推断	23621087	GOA
involved in response to fructose	IDA IDA: 通过直接分析推断	14627435	GOA
involved in response to glucose	IDA IDA: 通过直接分析推断	14627435	GOA
involved in triglyceride homeostasis	IMP IMP: 通过突变表型推断	19526250	GOA
involved in urate metabolic process	IMP IMP: 通过突变表型推断	19503597	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

glucokinase regulatory protein

glucokinase (hexokinase 4) regulator

GCKR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GCKR	Q14397	GCK	Homo sapiens	P35557	Phage Display	11522786
种属内	GCKR	Q14397	GCK	Homo sapiens	P35557	ELISA	11522786

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GCKR 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71822	GCKR Protein, Human (P.pastoris, His)	Q14397 (M1-Q625)	≥95%

关联疾病

疾病名称

别名

Fasting Plasma Glucose Level Quantitative Trait Locus 5

Fasting Plasma Glucose Level Qtl 5

FGQTL5

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Hyperglycemia

Maturity-Onset Diabetes Of The Young, Type 2

Maturity-Onset Diabetes Of The Young Type 2	MODY2
Mody Glucokinase-Related	Mody Type 2
Mody, Type 2	Mody, Glucokinase-Related
Mody, Type Ii	Maturity-Onset Diabetes Of The Young 2
Mody-2	Diabetes Of The Young, Maturity-Onset, Type 2
Diabetes Mellitus Autosomal Dominant Type Ii

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Hyperinsulinism

Hyperinsulinemia

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Fructosuria, Essential

Essential Fructosuria	Ketohexokinase Deficiency
Fructosuria	Hepatic Fructokinase Deficiency
Fructokinase Deficiency	FRUCT
Deficiency Of Fructokinase

Permanent Neonatal Diabetes Mellitus

Pndm	Permanent Diabetes Mellitus Of Infancy
Pdmi	Neonatal Diabetes Mellitus, Permanent

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diabetes Mellitus

Diabetes

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05332	GCKR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GCKR	RGD	RGD:2671
Macaca mulatta	GCKR	VGNC	VGNC:72902
Canis familiaris	GCKR	VGNC	VGNC:97197
Mus musculus	GCKR	MGD	MGI:1096345
Others	GCKR	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GCKR - glucokinase regulator Gene

关于 GCKR

功能概要

GCKR 基因产物(1)

GCKR 蛋白互作信息

重组 GCKR 蛋白

关联疾病

直系同源

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GCKR - glucokinase regulator Gene

关于 GCKR

功能概要

GCKR 基因产物(1)

GCKR 蛋白互作信息

重组 GCKR 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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