TIMM10 - translocase of inner mitochondrial membrane 10 Gene

中文名称：线粒体内膜转位酶 10

种属: Homo sapiens

同用名: TIM10; TIM10A; TIMM10A

基因 ID: 26519 | 基因类型: protein coding

关于 TIMM10

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,528,464-57,530,754 (from NCBI)

This gene has 3 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in kidney (RPKM 18.4), liver (RPKM 14.8) and 25 other tissues.

功能概要

由该基因编码的线粒体蛋白属于进化上保守的蛋白家族，这些蛋白在线粒体膜间隙中以异源寡聚复合物的形式排列。这些蛋白质介导疏水性膜蛋白导入和插入线粒体内膜，充当高度不溶性载体蛋白的膜间空间伴侣。[RefSeq 提供，2011 年 11 月]

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

TIMM10 基因产物(1)

mRNA	Protein	Name
NM_012456.3	NP_036588.1	mitochondrial import inner membrane translocase subunit Tim10

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables membrane insertase activity	IDA IDA: 通过直接分析推断	16387659	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14726512	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	16387659	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	16387659	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein insertion into mitochondrial inner membrane	IDA IDA: 通过直接分析推断	16387659	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TIM22 mitochondrial import inner membrane insertion complex	IPI IPI: 通过物理相互作用推断	32901109	GOA
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	14726512	GOA
located in mitochondrial intermembrane space	IDA IDA: 通过直接分析推断	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IDA IDA: 通过直接分析推断	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IPI IPI: 通过物理相互作用推断	14726512	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIMM10 蛋白结构

zf-Tim10_DDP

0
90 a.a.

蛋白主名

其他名称

mitochondrial import inner membrane translocase subunit Tim10

translocase of inner mitochondrial membrane 10 homolog

TIMM10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TIMM10	P62072	TIMM9	Homo sapiens	Q9Y5J7	Anti Bait CoIP	14726512
种属内	TIMM10	P62072	TIMM9	Homo sapiens	Q9Y5J7	GMS	14726512
种属内	TIMM10	P62072	TIMM9	Homo sapiens	Q9Y5J7	Anti Tag CoIP	33961781
种属内	TIMM10	P62072	TBC1D21	Homo sapiens	Q8IYX1	Validated Y2H	32296183
种属内	TIMM10	P62072	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
种属内	TIMM10	P62072	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
种属内	TIMM10	P62072	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mohr-Tranebjaerg Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome	Jensen Syndrome
Deafness Dystonia Syndrome	MTS
Dds	Deafness-Dystonia-Optic Atrophy Syndrome
Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency	Opticoacoustic Nerve Atrophy With Dementia
Dystonia-Deafness Syndrome	Ddp
Ddon Syndrome	Mohr-Tranebjærg Syndrome
Deafness Dystonia Optic Atrophy Syndrome	Deafness Dystonia Optic Neuronopathy Syndrome
Dystonia Deafness Syndrome	Ddon
Deafness - Dystonia - Optic Neuronopathy Syndrome	Deafness-Dystonia-Optic Neuronopathy Syndrome
Hearing Loss-Dystonia-Optic Neuronopathy Syndrome	Dfn-1
X-Linked Progressive Deafness Type 1

Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Visual Pathway Disease

Disorder Of Visual Pathways

Lymph Node Tuberculosis

King'S Evil	Scrofula
Tuberculous Adenitis	Tuberculous Lymphadenopathy
Tuberculosis, Lymph Node

Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28	SCA28
Ataxia, Spinocerebellar, Type 28

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Cortical Blindness

Blindness, Cortical

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14527	TIMM10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TIMM10	VGNC	VGNC:81928
Mus musculus	TIMM10	MGD	MGI:1353429
Canis familiaris	TIMM10	VGNC	VGNC:49618
Bos taurus	TIMM10	VGNC	VGNC:97317
Macaca mulatta	TIMM10	VGNC	VGNC:107651
Rattus norvegicus	TIMM10	RGD	RGD:621741

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