2. Gene
  3. TIMM9 - translocase of inner mitochondrial membrane 9 Gene

TIMM9 - translocase of inner mitochondrial membrane 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：线粒体内膜转位酶 9

种属: Homo sapiens

同用名: TIM9; TIM9A

基因 ID: 26520 | 基因类型: protein coding

关于 TIMM9

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,408,494-58,427,531 (from NCBI)

This gene has 10 transcripts (splice variants) and 167 orthologues. Ubiquitous expression in thyroid (RPKM 11.9), ovary (RPKM 11.7) and 25 other tissues.

功能概要

TIMM9 属于进化上保守的蛋白质家族，这些蛋白质在线粒体膜间隙中以异源寡聚复合物的形式组织。这些蛋白质介导疏水性膜蛋白导入和插入线粒体内膜。[OMIM 提供，2004 年 4 月]

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

TIMM9 基因产物(8)

mRNA Protein Name
NM_001304485.2 NP_001291414.1 mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304486.1 NP_001291415.1 mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304487.2 NP_001291416.1 mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304488.1 NP_001291417.1 mitochondrial import inner membrane translocase subunit Tim9 isoform b
NM_001304489.1 NP_001291418.1 mitochondrial import inner membrane translocase subunit Tim9 isoform c
NM_001304490.1 NP_001291419.1 mitochondrial import inner membrane translocase subunit Tim9 isoform d
NM_001304491.1 NP_001291420.1 mitochondrial import inner membrane translocase subunit Tim9 isoform d
NM_012460.4 NP_036592.1 mitochondrial import inner membrane translocase subunit Tim9 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables membrane insertase activity IDA
IDA: 通过直接分析推断
16387659 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14726512 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
16387659 GOA
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
16387659 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein insertion into mitochondrial inner membrane IDA
IDA: 通过直接分析推断
16387659 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TIM22 mitochondrial import inner membrane insertion complex IPI
IPI: 通过物理相互作用推断
32901109 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
14726512 GOA
located in mitochondrial intermembrane space IDA
IDA: 通过直接分析推断
14726512 GOA
part of mitochondrial intermembrane space protein transporter complex IDA
IDA: 通过直接分析推断
14726512 GOA
part of mitochondrial intermembrane space protein transporter complex IPI
IPI: 通过物理相互作用推断
14726512 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIMM9 蛋白结构

zf-Tim10_DDP

zf-Tim10_DDP: Tim10/DDP family zinc finger (9 - 69)

  • 0
  • 89 a.a.
蛋白主名 其他名称

mitochondrial import inner membrane translocase subunit Tim9

translocase of inner mitochondrial membrane 9 homolog

TIMM9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TIMM9 Q9Y5J7 TIMM10 Homo sapiens P62072
Anti Bait CoIP
14726512
种属内
TIMM9 Q9Y5J7 TIMM10 Homo sapiens P62072
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mohr-Tranebjaerg Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome

Jensen Syndrome

Deafness Dystonia Syndrome

MTS

Dds

Deafness-Dystonia-Optic Atrophy Syndrome

Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency

Opticoacoustic Nerve Atrophy With Dementia

Dystonia-Deafness Syndrome

Ddp

Ddon Syndrome

Mohr-Tranebjærg Syndrome

Deafness Dystonia Optic Atrophy Syndrome

Deafness Dystonia Optic Neuronopathy Syndrome

Dystonia Deafness Syndrome

Ddon

Deafness - Dystonia - Optic Neuronopathy Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome

Hearing Loss-Dystonia-Optic Neuronopathy Syndrome

Dfn-1

X-Linked Progressive Deafness Type 1
Myoclonic Epilepsy, Juvenile 3

Myoclonic Epilepsy, Juvenile, Susceptibility To, 3

EJM3

Epilepsy, Juvenile Myoclonic 3

Juvenile Myoclonic Epilepsy 3
Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type
Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10

Cardiomyopathy And Cataract

Cataract And Cardiomyopathy

MTDPS10

Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

Senger Syndrome
Visual Cortex Disease

Visual Cortex Dysfunction

Visual Cortex Disorder

Visual Cortical Disorder

Disease Of Visual Cortex
Visual Pathway Disease

Disorder Of Visual Pathways
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14536 TIMM9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TIMM9 MGD MGI:1353436
Bos taurus TIMM9 VGNC VGNC:55149
Canis familiaris TIMM9 VGNC VGNC:49625
Rattus norvegicus TIMM9 RGD RGD:621656
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