GDI2 - GDP dissociation inhibitor 2 Gene

中文名称：GDP 解离抑制因子 2

种属: Homo sapiens

同用名: RABGDIB; HEL-S-46e

关于 GDI2

功能概要

GDP 解离抑制剂是调节 rab 家族成员 GDP-GTP 交换反应的蛋白质，Ras 超家族的小 GTP 结合蛋白，参与细胞器之间分子的囊泡运输。 GDI 减缓了 GDP 从 rab 蛋白的解离速度，并从膜结合的 rabs 中释放 GDP。 GDI2 被广泛表达。 GDI2 基因包含许多重复元素，表明它可能容易发生倒位/缺失重排。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]