2. Gene
  3. Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 4

种属: Mus musculus

同用名: HGK; Nik; 9430080K19Rik

基因 ID: 26921 | 基因类型: protein coding

关于 Map4k4

Chromosome 1: 39,940,073-40,065,470 forward strand.GRCm39:CM000994.3

This gene has 18 transcripts (splice variants), 281 orthologues, 35 paralogues and is associated with 6 phenotypes. Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括细胞-基质连接组织的正调控；细胞内信号转导的正向调节；和角质形成细胞迁移的正调节。位于粘着斑。以多种结构表达，包括泌尿生殖系统；磨牙;神经系统;神经视网膜;和皮肤。与人 MAP4K4（丝裂原活化蛋白激酶激酶 kinase kinase 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map4k4 基因产物(4)

mRNA Protein Name
NM_001252201.1 NP_001239130.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3
NM_008696.2 NP_032722.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2
NM_001252200.1 NP_001239129.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
NM_001252202.1 NP_001239131.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9135144 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16938849 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9135144 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of ARF protein signal transduction IMP
IMP: 通过突变表型推断
25490267 MGI
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
25490267 MGI
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
9135144 MGI
involved in positive regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
25490267 MGI
involved in positive regulation of focal adhesion disassembly IMP
IMP: 通过突变表型推断
25490267 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: 通过突变表型推断
25490267 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9135144 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
25490267 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Map4k4 蛋白结构

PKc_like

PKc_like: cl21453 (7 - 288)

CNH

CNH: smart00036 (969 - 1267)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1288 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 4

HPK/GCK-like kinase HGK

MAPK/ERK kinase kinase kinase 4

MEK kinase kinase 4

MEKKK 4

NCK interacting kinase

nck-interacting kinase

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100343 GNE-495 Inhibitor 99.40% 否
HY-111754 DMX-5804 Inhibitor 99.83% 否
HY-19562 PF-06260933 Inhibitor 99.67% 否
HY-125012 MAP4K4-IN-3 Inhibitor 99.15% 否
HY-132290 TGFβRI-IN-3 Inhibitor 98.21% 否
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% 否
HY-160623 INS018 055 Inhibitor 99.38% 否
HY-U00428 GNE 220 Inhibitor / 否
HY-156523 TNIK&MAP4K4-IN-1 / 否
HY-162922 MAP4K4-IN-6 Inhibitor / 否
HY-RS08080 MAP4K4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08081 Map4k4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08082 Map4k4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-19562A PF-06260933 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map4k4 NCBI NCBI:9448
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