DNAJC2 - DnaJ heat shock protein family (Hsp40) member C2 Gene

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 C2

种属: Homo sapiens

同用名: ZRF1; ZUO1; MPP11; MPHOSPH11

关于 DNAJC2

功能概要

该基因是 M 期磷蛋白 (MPP) 家族的成员。该基因编码具有 J 结构域和 Myb DNA 结合结构域的磷蛋白，后者定位于细胞核和胞质溶胶。该蛋白质能够形成与核糖体结合的异二聚体复合物，作为新生多肽链离开核糖体时的分子伴侣。这种蛋白质被鉴定为白血病相关抗原，并且该基因的表达在白血病母细胞中上调。此外，涉及该基因的染色体畸变与原发性头颈部鳞状细胞肿瘤有关。该基因在 6 号染色体上有一个假基因。已经描述了编码不同蛋白质同种型的可变剪接变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]