2. Gene
  3. HSPA14 - heat shock protein family A (Hsp70) member 14 Gene

HSPA14 - heat shock protein family A (Hsp70) member 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热休克蛋白家族 A (Hsp70) 成员 14

种属: Homo sapiens

同用名: HSP70-4; HSP70L1; MSANTD7

基因 ID: 51182 | 基因类型: protein coding

关于 HSPA14

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,838,306-14,871,741 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues.

功能概要

预计将启用多种功能，包括 ATP 绑定活动；错误折叠的蛋白质结合活性；和未折叠的蛋白结合活性。预计参与多个过程，包括细胞对未折叠蛋白的反应；伴侣辅助因子依赖性蛋白质重折叠；和蛋白质重折叠。位于胞质溶胶中。与核糖体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in cytosol. Colocalizes with ribosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA14 基因产物(1)

mRNA Protein Name
NM_016299.4 NP_057383.2 heat shock 70 kDa protein 14
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16002468 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
16002468 GOA
colocalizes with ribosome IDA
IDA: 通过直接分析推断
16002468 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSPA14 蛋白结构

HSP70

HSP70: Hsp70 protein (3 - 506)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
蛋白主名 其他名称

heat shock 70 kDa protein 14

HSP70-like protein 1

HSPA14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HSPA14 Q0VDF9 DNAJC2 Homo sapiens Q99543
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autoimmune Atherosclerosis
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06423 HSPA14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HSPA14 MGD MGI:1354164
Felis catus HSPA14 VGNC VGNC:84034
Rattus norvegicus HSPA14 RGD RGD:1303296
Macaca mulatta HSPA14 VGNC VGNC:106060
Canis familiaris HSPA14 VGNC VGNC:52137
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