1. Gene
  2. UBE2S - ubiquitin conjugating enzyme E2 S Gene

UBE2S - ubiquitin conjugating enzyme E2 S Gene

中文名称:泛素结合酶 E2 S

种属: Homo sapiens

同用名: EPF5; E2EPF; E2-EPF

基因 ID: 27338 | 基因类型: protein coding

关于 UBE2S

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,399,745-55,407,788 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 24 paralogues. Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues.

功能概要

该基因编码泛素结合酶家族的一个成员。编码的蛋白质能够以泛素激活酶依赖性方式与泛素形成硫醇酯键,这是泛素载体蛋白的一个特征。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the ubiquitin-conjugating Enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

UBE2S 基因产物(1)

mRNA Protein Name
NM_014501.3 NP_055316.2 ubiquitin-conjugating enzyme E2 S
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables anaphase-promoting complex binding IPI
IPI: 通过物理相互作用推断
23708001 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23708001 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
21376237 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
19820702 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
20061386 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: 通过直接分析推断
19820702 GOA
involved in exit from mitosis IDA
IDA: 通过直接分析推断
19820702 GOA
involved in exit from mitosis IMP
IMP: 通过突变表型推断
19822757 GOA
involved in free ubiquitin chain polymerization IDA
IDA: 通过直接分析推断
19822757 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
19820702 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27910872 GOA
acts upstream of or within protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
21376237 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
19822757 GOA
involved in protein K27-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K29-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K6-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of anaphase-promoting complex IDA
IDA: 通过直接分析推断
19822757 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBE2S 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (16 - 149)

  • 0
  • 100
  • 200
  • 222 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 S

E2 ubiquitin-conjugating enzyme S

UBE2S 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2S Q16763 GNB2 Homo sapiens P62879 32814053
种属内
UBE2S Q16763 GNB2 Homo sapiens P62879 32814053
种属内
UBE2S Q16763 GNB2 Homo sapiens P62879 32814053
种属内
UBE2S Q16763 ANAPC2 Homo sapiens Q9UJX6 23708001
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2S 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71408 UBE2S Protein, Human (GST) Q16763 (M1-L222) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language

Chromosome 5q14.3 Deletion Syndrome

5q14.3 Microdeletion Syndrome

Mental Retardation, Autosomal Dominant 20

NEDHSIL

Autosomal Dominant Mental Retardation 20

Mrd20

Del(5)(Q14.3)

Monosomy 5q14.3

Intellectual Disability, Autosomal Dominant 20

Mental Retardation, Autosomal Dominant 20, Formerly

Mrd20, Formerly

Mental Retardation, Stereotypic Movements, Epilepsy, And/Or Cerebral Malformations

5q14.3 Deletion Syndrome

Autosomal Dominant Intellectual Disability 20

Mental Retardation, Autosomal Dominant, Type 20

Liddle Syndrome 1

Liddle Syndrome

Pseudoaldosteronism

Liddle'S Syndrome

LIDLS1

Lidls

Pseudohyperaldosteronism

Pseudoprimary Hyperaldosteronism

Pseudohyperaldosteronism Type 1

Liddles Syndrome

Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease

Uterine Adnexa Cancer
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1

Hypophosphatemic Nephrolithiasis/Osteoporosis 1

NPHLOP1

Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1

Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6

CDCBM6

Cdcbm56

Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris UBE2S VGNC VGNC:48065
Macaca mulatta UBE2S VGNC VGNC:79099
Felis catus UBE2S VGNC VGNC:107073
Bos taurus UBE2S VGNC VGNC:36595
Rattus norvegicus UBE2S RGD RGD:1564746
Mus musculus UBE2S MGD MGI:1925141
Others UBE2S NCBI