GNB2 - G protein subunit beta 2 Gene

中文名称：G 蛋白亚基β2

种属: Homo sapiens

同用名: SSS4; HG2C1; SSS4; NEDHYDF

基因 ID: 2783 | 基因类型: protein coding

关于 GNB2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,673,740-100,679,169 (from NCBI)

This gene has 13 transcripts (splice variants), 194 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 67.4), prostate (RPKM 65.4) and 25 other tissues.

功能概要

异源三聚体鸟嘌呤核苷酸结合蛋白 (G 蛋白) 整合受体和效应蛋白之间的信号，由 alpha、beta 和 gamma 亚基组成。这些亚基由相关基因家族编码。该基因编码一个β亚基。 β 亚基是 α 亚基以及某些信号转导受体和效应器的重要调节剂。该基因在其 5' UTR 中包含一个三核苷酸 (CCG) 重复长度多态性。[RefSeq 提供，2008 年 7 月]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

GNB2 基因产物(1)

mRNA	Protein	Name
NM_005273.4	NP_005264.2	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase binding	IPI IPI: 通过物理相互作用推断	19255495	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16498633	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	23209302	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of potassium ion transmembrane transport	IMP IMP: 通过突变表型推断	28219978	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	16498633	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	28219978	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNB2 蛋白结构

WD40

0
100
200
300
340 a.a.

蛋白主名

其他名称

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

G protein, beta-2 subunit

GNB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GNB2	P62879	UBE2Q1	Homo sapiens	Q7Z7E8-2	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2Q1	Homo sapiens	Q7Z7E8-2	Y2H Array	32814053
种属内	GNB2	P62879	UBE2Q1	Homo sapiens	Q7Z7E8-2	Y2H Pooling	32814053
种属内	GNB2	P62879	ATG10	Homo sapiens	Q9H0Y0	Y2H Pooling	32814053
种属内	GNB2	P62879	ATG10	Homo sapiens	Q9H0Y0	Validated Y2H	32814053
种属内	GNB2	P62879	ATG10	Homo sapiens	Q9H0Y0	Y2H Array	32814053
种属内	GNB2	P62879	UBE2L6	Homo sapiens	O14933	Y2H Array	32814053
种属内	GNB2	P62879	UBE2L6	Homo sapiens	O14933	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2L6	Homo sapiens	O14933	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2Q2	Homo sapiens	Q8WVN8	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2Q2	Homo sapiens	Q8WVN8	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2Q2	Homo sapiens	Q8WVN8	Y2H Array	32814053
种属内	GNB2	P62879	UBE2U	Homo sapiens	Q5VVX9-2	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2U	Homo sapiens	Q5VVX9-2	Y2H Array	32814053
种属内	GNB2	P62879	UBE2U	Homo sapiens	Q5VVX9-2	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2O	Homo sapiens	Q9C0C9	Y2H Array	32814053
种属内	GNB2	P62879	UBE2O	Homo sapiens	Q9C0C9	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2O	Homo sapiens	Q9C0C9	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2J2	Homo sapiens	Q8N2K1	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2J2	Homo sapiens	Q8N2K1	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2J2	Homo sapiens	Q8N2K1	Y2H Array	32814053
种属内	GNB2	P62879	UBE2D2	Homo sapiens	P62837	Y2H Array	32814053
种属内	GNB2	P62879	UBE2D2	Homo sapiens	P62837	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2D2	Homo sapiens	P62837	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2D3	Homo sapiens	P61077	Y2H Pooling	32814053
种属内	GNB2	P62879	UBE2D3	Homo sapiens	P61077	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2D3	Homo sapiens	P61077	Y2H Array	32814053
种属内	GNB2	P62879	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
种属内	GNB2	P62879	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
种属内	GNB2	P62879	TARDBP	Homo sapiens	Q13148	Anti Tag CoIP	28514442
种属内	GNB2	P62879	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
种属内	GNB2	P62879	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	GNB2	P62879	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	GNB2	P62879	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	GNB2	P62879	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	GNB2	P62879	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	GNB2	P62879	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	GNB2	P62879	UBE2D1	Homo sapiens	P51668	Validated Y2H	32814053
种属内	GNB2	P62879	UBE2D1	Homo sapiens	P51668	Y2H Array	32814053
种属内	GNB2	P62879	UBE2D1	Homo sapiens	P51668	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

GNB2 抗体

目录号	产品名	应用	反应物种
HY-P81868	GNB2 Antibody (YA1613)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Sick Sinus Syndrome 4

SSS4

Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies

NEDHYDF

Sturge-Weber Syndrome

SWS	Encephalotrigeminal Angiomatosis
Encephalofacial Angiomatosis	Sturge-Weber-Dimitri Syndrome
Sturge-Weber-Krabbe Syndrome	Fourth Phacomatosis
Leptomeningeal Angiomatosis	Meningeal Capillary Angiomatosis
Sturge-Weber-Krabbe Angiomatosis	Sturge-Weber Syndrome, Somatic, Mosaic
Sws Type I - Facial And Leptomeningeal Angiomas	Sws Type Ii - Facial Angioma Alone, No Cns Involvement
Sws Type Iii - Isolated Leptomeningeal Angiomas	Sturge Weber Syndrome
Angiomatosis Aculoorbital-Thalamic Syndrome	Encephalofacial Hemangiomatosis
Encephalofacial Hemangiomatosis Syndrome	Meningo-Oculo-Facial Angiomatosis
Meningofacial Angiomatosis-Cerebral Calcification Syndrome	Neuroretinoangiomatosis
Phakomatosis, Sturge-Weber	Weber-Sturge-Dimitri Syndrome

Sick Sinus Syndrome

Sinus Node Dysfunction	Sinus Node Disease
Sinus Node Infection	Snd
Sss	Snd - [Sinus Node Dysfunction]
Sinoatrial Node Dysfunction	Sss - [Sick Sinus Syndrome]
Sick Sinus	Sick Sinus Tachycardia

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

Progressive Familial Heart Block, Type Ib

Progressive Familial Heart Block Type Ib	PFHB1B
Pfhbib	Progressive Familial Heart Block Type 1b
Heart Block Progressive Familial Type 1b	Progressive Familial Heart Block 1b
Cardiac Conduction Block	Right-Bundle Branch Block
Heart Block, Familial, Progressive, Type 1b	Heart Block
Right Bundle Branch Block

Weber Syndrome

Midbrain Stroke Syndromes

Night Blindness, Congenital Stationary, Autosomal Dominant 2

Congenital Stationary Night Blindness Autosomal Dominant 2	CSNBAD2
Hemeralopia	Night Blindness, Congenital Stationary, Rambusch Type
Rambusch Type Congenital Stationary Night Blindness	Congenital Stationary Night Blindness Rambusch Type
Hemeralopia Congenital Essential	Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05547	GNB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GNB2	RGD	RGD:69319
Mus musculus	GNB2	MGD	MGI:95784
Canis familiaris	GNB2	VGNC	VGNC:41313
Macaca mulatta	GNB2	VGNC	VGNC:81318
Felis catus	GNB2	VGNC	VGNC:62621
Bos taurus	GNB2	VGNC	VGNC:29459
Others	GNB2	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4