GNAI2 - G protein subunit alpha i2 Gene

中文名称：G 蛋白亚基αi2

种属: Homo sapiens

同用名: GIP; HG1C; GNAI2B; H_LUCA15.1; H_LUCA16.1

基因 ID: 2771 | 基因类型: protein coding

关于 GNAI2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,227,068-50,263,358 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues, 15 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 106.7), bone marrow (RPKM 93.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是鸟嘌呤核苷酸结合蛋白 (G 蛋白) 的 α 亚基。编码的蛋白质包含鸟嘌呤核苷酸结合位点，并参与腺苷酸环化酶的激素调节。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of Adenylate Cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GNAI2 基因产物(6)

mRNA	Protein	Name
NM_001166425.2	NP_001159897.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 2
NM_001282617.2	NP_001269546.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 3
NM_001282618.2	NP_001269547.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 4
NM_001282619.2	NP_001269548.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 5
NM_001282620.2	NP_001269549.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 6
NM_002070.4	NP_002061.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell division	IMP IMP: 通过突变表型推断	17635935	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	21079996	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	17635935	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17635935	GOA
located in midbody	IDA IDA: 通过直接分析推断	17635935	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	17635935	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNAI2 蛋白结构

G-alpha

0
100
200
300
355 a.a.

蛋白主名

其他名称

guanine nucleotide-binding protein G(i) subunit alpha-2

GTP-binding regulatory protein Gi alpha-2 chain

GNAI2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	GNAI2	P04899	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	GNAI2	P04899	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	GNAI2	P04899	RGS20	Homo sapiens	O76081-6	Y2H Array	25416956
Intra	GNAI2	P04899	PCP2	Homo sapiens	Q8IVA1	Validated Y2H	32296183
Intra	GNAI2	P04899	CXCR5	Homo sapiens	P32302	CoIP	15251452
Intra	GNAI2	P04899	CXCR5	Homo sapiens	P32302	Anti Bait CoIP	23773523
Intra	GNAI2	P04899	CXCR5	Homo sapiens	P32302	Experimental Interac	15251452
Intra	GNAI2	P04899	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	25416956
Intra	GNAI2	P04899	GPSM3	Homo sapiens	Q9Y4H4	Y2H Prey Pooling	25416956
Intra	GNAI2	P04899	GNB1	Homo sapiens	P62873	Anti Tag CoIP	33961781
Intra	GNAI2	P04899	NCF1	Homo sapiens	P14598	Anti Bait CoIP	16782902
Cross	GNAI2	P04899	Oprm1	Mus musculus	P42866	Anti Bait CoIP	18599439
Cross	GNAI2	P04899	Oprm1	Mus musculus	P42866	Anti Tag CoIP	18599439
Intra	GNAI2	P04899	MDFI	Homo sapiens	Q99750	Pull Down	16189514
Intra	GNAI2	P04899	MDFI	Homo sapiens	Q99750	Y2H Pooling	16189514
Intra	GNAI2	P04899	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
Intra	GNAI2	P04899	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ventricular Tachycardia, Familial

Familial Ventricular Tachycardia	Ventricular Tachycardia, Familial Polymorphic
Ventricular Tachycardia, Idiopathic

Granulosa Cell Tumor Of The Ovary

Adult Granulosa Cell Tumor Of The Ovary	Gct Of The Ovary
Gtct	Granulosa Theca Cell Tumor
Granulosa Theca Cell Tumor Of The Ovary

Pituitary Adenoma 4, Acth-Secreting

PITA4	Cushing Disease, Pituitary
Pituitary Adenoma 4, Acth-Secreting, Somatic	Cushing Disease
Pituitary Cushing Disease	Adenoma, Pituitary, Acth-Secreting, Type 4
Pituitary-Dependent Cushing'S Disease

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05535	GNAI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	GNAI2	VGNC	VGNC:62617
Rattus norvegicus	GNAI2	RGD	RGD:620243
Mus musculus	GNAI2	MGD	MGI:95772
Canis familiaris	GNAI2	VGNC	VGNC:41302
Bos taurus	GNAI2	VGNC	VGNC:29450
Macaca mulatta	GNAI2	VGNC	VGNC:73090

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GNAI2 - G protein subunit alpha i2 Gene

关于 GNAI2

功能概要

GNAI2 基因产物(6)

GNAI2 蛋白结构

GNAI2 蛋白互作信息

关联疾病

直系同源

热门区域

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GNAI2 - G protein subunit alpha i2 Gene

关于 GNAI2

功能概要

GNAI2 基因产物(6)

GNAI2 蛋白结构

GNAI2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z