HIPK2 - homeodomain interacting protein kinase 2 Gene

中文名称：同源结构域相互作用蛋白激酶 2

种属: Homo sapiens

同用名: PRO0593

基因 ID: 28996 | 基因类型: protein coding

关于 HIPK2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,561,570-139,777,998 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues.

功能概要

该基因编码一种保守的丝氨酸/苏氨酸激酶，它是同源结构域相互作用蛋白激酶家族的成员。编码的蛋白质与同源结构域转录因子和许多其他转录因子 (如 p53) 相互作用，并且可以根据转录因子及其亚细胞定位同时充当共抑制因子和共激活因子。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 11 月]

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many Other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

HIPK2 基因产物(2)

mRNA	Protein	Name
NM_001113239.3	NP_001106710.1	homeodomain-interacting protein kinase 2 isoform 2
NM_022740.5	NP_073577.3	homeodomain-interacting protein kinase 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	14647468	GOA
enables SMAD binding	IPI IPI: 通过物理相互作用推断	12874272	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12220523	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	19448668	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	33591310	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	12874272	GOA
enables virion binding	IPI IPI: 通过物理相互作用推断	14990717	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response, signal transduction by p53 class mediator	IDA IDA: 通过直接分析推断	14647468	GOA
involved in SMAD protein signal transduction	IDA IDA: 通过直接分析推断	12874272	GOA
involved in negative regulation of BMP signaling pathway	IMP IMP: 通过突变表型推断	12874272	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	21628596	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	33591310	GOA
involved in positive regulation of JNK cascade	IMP IMP: 通过突变表型推断	14678985	GOA
involved in positive regulation of angiogenesis	IDA IDA: 通过直接分析推断	19046997	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	14647468	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	14678985	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	19448668	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with PML body	IDA IDA: 通过直接分析推断	14647468	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	33591310	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	33591310	GOA
located in nuclear body	IDA IDA: 通过直接分析推断	12874272	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12220523	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HIPK2 蛋白结构

Pkinase

0
200
400
600
800
1000
1198 a.a.

蛋白主名

其他名称

homeodomain-interacting protein kinase 2

hHIPk2

HIPK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HIPK2	Q9H2X6	MECP2	Homo sapiens	P51608	Anti Bait CoIP	19820693
种属内	HIPK2	Q9H2X6	TP63	Homo sapiens	Q9H3D4	Protein Kinase Assay	21602882
种属内	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Anti Tag CoIP	20940704
种属内	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Y2H	20940704
种属内	HIPK2	Q9H2X6	DCAF7	Homo sapiens	P61962	Pull Down	20940704
种属内	HIPK2	Q9H2X6	EP300	Homo sapiens	Q09472	Pull Down	16917507
种属内	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Pull Down	16917507
种属内	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Anti Bait CoIP	16917507
种属内	HIPK2	Q9H2X6	RUNX1	Homo sapiens	Q01196	Protein Kinase Assay	16917507

种属间: 跨种属相互作用 种属内: 同种属相互作用

HIPK2 抗体

目录号	产品名	应用	反应物种
HY-P82168	HIPK2 Antibody (YA1913)	WB, ICC/IF, IP, FC	Human, Mouse

关联疾病

疾病名称

别名

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100464	tBID	Inhibitor	99.03%	否
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	否
HY-135906	CK2/ERK8-IN-1		≥99.0%	否
HY-128439	BT173	Inhibitor	98.71%	否
HY-U00439	Protein kinase inhibitor 1	Inhibitor	≥99.0%	否
HY-RS06182	HIPK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	HIPK2	MGD	MGI:1314872
Macaca mulatta	HIPK2	VGNC	VGNC:73391
Rattus norvegicus	HIPK2	RGD	RGD:1309349
Bos taurus	HIPK2	VGNC	VGNC:58380
Canis familiaris	HIPK2	VGNC	VGNC:41694
Felis catus	HIPK2	VGNC	VGNC:62820

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HIPK2 - homeodomain interacting protein kinase 2 Gene

关于 HIPK2

功能概要

HIPK2 基因产物(2)

HIPK2 蛋白结构

HIPK2 蛋白互作信息

HIPK2 抗体

关联疾病

直系同源

热门区域

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HIPK2 - homeodomain interacting protein kinase 2 Gene

关于 HIPK2

功能概要

HIPK2 基因产物(2)

HIPK2 蛋白结构

HIPK2 蛋白互作信息

HIPK2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z