ATAD2 - ATPase family AAA domain containing 2 Gene

中文名称：含 ATPase 家族 AAA 结构域 2

种属: Homo sapiens

同用名: ANCCA; CT137; PRO2000

基因 ID: 29028 | 基因类型: protein coding

关于 ATAD2

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:123,319,850-123,416,350 (from NCBI)

This gene has 8 transcripts (splice variants), 232 orthologues and 1 paralogue. Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues.

功能概要

已经描述了一大类 ATP 酶，其主要特征是它们共享一个约 220 个氨基酸的保守区域，该区域包含一个 ATP 结合位点。属于该家族的蛋白质包含一个或两个 AAA (与不同细胞活动相关的 ATP 酶) 结构域。 AAA 家族蛋白通常执行类似伴侣的功能，协助蛋白质复合物的组装、操作或分解。该基因编码的蛋白质包含两个 AAA 结构域和一个溴结构域。[RefSeq 提供，2008 年 7 月]

A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 Amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

ATAD2 基因产物(1)

mRNA	Protein	Name
NM_014109.4	NP_054828.2	ATPase family AAA domain-containing protein 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP hydrolysis activity	IDA IDA: 通过直接分析推断	17998543	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17998543	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17998543	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	25593309	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATAD2 蛋白结构

AAA

Bromodomain

0
300
600
900
1200
1390 a.a.

蛋白主名

其他名称

ATPase family AAA domain-containing protein 2

AAA nuclear coregulator cancer-associated protein

ATAD2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ATAD2	Q6PL18	ESR1	Homo sapiens	P03372	Anti Bait CoIP	17998543
种属内	ATAD2	Q6PL18	ESR1	Homo sapiens	P03372	Pull Down	17998543
种属内	ATAD2	Q6PL18	NCOA3	Homo sapiens	Q9Y6Q9	Pull Down	17998543
种属内	ATAD2	Q6PL18	NCOA3	Homo sapiens	Q9Y6Q9	Anti Bait CoIP	17998543

种属间: 跨种属相互作用 种属内: 同种属相互作用

ATAD2 抗体

目录号	产品名	应用	反应物种
HY-P82049	ATAD2 Antibody (YA1794)	WB, ICC/IF, FC	Human

关联疾病

疾病名称

别名

Uterine Corpus Endometrial Carcinoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119254	BAY-850	Inhibitor	98.33%	否
HY-136521	AZ13824374	Inhibitor	98.86%	否
HY-114204	GSK8814	Inhibitor	99.60%	否
HY-119254A	trans-BAY-850	Control	/	否
HY-163108	ATAD2-IN-1		/	否
HY-P10326	Z-ATAD-FMK	Inhibitor	/	否
HY-RS01119	ATAD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01120	ATAD2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ATAD2	VGNC	VGNC:59989
Mus musculus	ATAD2	MGD	MGI:1917722
Canis familiaris	ATAD2	VGNC	VGNC:38201
Rattus norvegicus	ATAD2	RGD	RGD:1304849
Bos taurus	ATAD2	VGNC	VGNC:26233
Macaca mulatta	ATAD2	VGNC	VGNC:70154

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