Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

中文名称：含核苷酸结合寡聚化结构域， 2

种属: Rattus norvegicus

同用名: Card15

关于 Nod2

功能概要

该基因编码的蛋白可启动胞壁酰二肽结合活性。参与多个过程，包括细胞对肽聚糖的反应；树突状细胞细胞因子产生的正调节；和对胞壁酰二肽的反应。位于细胞质中。结肠炎的生物标志物；大脑中动脉梗塞;和胰腺炎。该基因的人类直系同源物与多种疾病有关，包括 Blau 综合征；自身免疫性疾病（多种）；胃肠道癌；肠道疾病（多种）；和肺部疾病（多种）。与人 NOD2 同源（包含 2 的核苷酸结合寡聚化结构域）。 [由基因组资源联盟提供，2022 年 4 月]

Enables muramyl dipeptide binding activity. Involved in several processes, including cellular response to peptidoglycan; positive regulation of dendritic cell cytokine production; and response to muramyl dipeptide. Located in cytoplasm. Biomarker of colitis; middle cerebral artery infarction; and pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]