2. Gene
  3. Tyms - thymidylate synthetase Gene

Tyms - thymidylate synthetase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：胸苷酸合成酶

种属: Rattus norvegicus

基因 ID: 29261 | 基因类型: protein coding

关于 Tyms

Primary_assembly 9: 113,313,452-113,329,536 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 38 phenotypes. Biased expression in Thymus (RPKM 144.9), Spleen (RPKM 129.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括叶酸结合活性；蛋白质同二聚化活性；和胸苷酸合酶活性。参与多个过程，包括含核碱基的小分子代谢过程；对类固醇激素的反应；和对维生素的反应。位于线粒体和核仁中。用于研究膀胱癌。结直肠腺癌的生物标志物。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；血液系统癌症（多发性）；和类风湿性关节炎。与人 TYMS（胸苷酸合成酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including folic acid binding activity; protein homodimerization activity; and Thymidylate Synthase activity. Involved in several processes, including nucleobase-containing small molecule metabolic process; response to steroid hormone; and response to vitamin. Located in mitochondrion and nucleolus. Used to study urinary bladder Cancer. Biomarker of colorectal adenocarcinoma. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Tyms 基因产物(1)

mRNA Protein Name
NM_019179.2 NP_062052.1 thymidylate synthase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables folic acid binding IDA
IDA: 通过直接分析推断
7537805 RGD
enables heterocyclic compound binding IPI
IPI: 通过物理相互作用推断
9894005 RGD
enables mRNA binding IPI
IPI: 通过物理相互作用推断
9891091 RGD
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9894005 RGD
enables thymidylate synthase activity IDA
IDA: 通过直接分析推断
9894005 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cartilage development IEP
IEP: 通过表达模式推断
3471366 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
19628084 RGD
involved in dTMP biosynthetic process IDA
IDA: 通过直接分析推断
9894005 RGD
involved in developmental growth IEP
IEP: 通过表达模式推断
7471094 RGD
involved in intestinal epithelial cell maturation IEP
IEP: 通过表达模式推断
1260861 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
2707640 RGD
involved in pyrimidine nucleobase metabolic process IEP
IEP: 通过表达模式推断
9524100 RGD
involved in regulation of translation IDA
IDA: 通过直接分析推断
26315778 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
9524100 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
9305788 RGD
involved in response to folic acid IEP
IEP: 通过表达模式推断
9528665 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
2707640 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
9683817 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
9635926 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
8781506 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
10395942 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
7686361 RGD
involved in tetrahydrofolate metabolic process IEP
IEP: 通过表达模式推断
7503782 RGD
involved in uracil metabolic process IEP
IEP: 通过表达模式推断
2043679 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tyms 蛋白结构

PTZ00164

PTZ00164: cl36520 (20 - 306)

  • 0
  • 100
  • 200
  • 307 a.a.
蛋白主名 其他名称

thymidylate synthase

TS

TSase

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163538 TYM-3-98 / 否
HY-RS15304 TYMS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15305 Tyms Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15306 Tyms Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N3764 Diosbulbin C Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tyms NCBI NCBI:7298
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