GSTA4 - glutathione S-transferase alpha 4 Gene

中文名称：谷胱甘肽 S-转移酶 α 4

种属: Homo sapiens

同用名: GTA4; GSTA4-4

关于 GSTA4

功能概要

胞质和膜结合形式的谷胱甘肽 S-转移酶由两个不同的超基因家族编码。这些酶参与细胞防御有毒、致癌和具有药理学活性的亲电子化合物。目前，已鉴定出八种不同类别的可溶性细胞质哺乳动物谷胱甘肽 S-转移酶：α、κ、μ、ω、pi、sigma、theta 和 zeta。该基因编码属于α类的谷胱甘肽 S-转移酶。位于 6 号染色体簇中的 alpha 类基因高度相关并编码具有谷胱甘肽过氧化物酶活性的酶，其在脂质过氧化产物的解毒中起作用。氧化代谢产生的反应性亲电子试剂与许多退行性疾病有关，包括帕金森病、阿尔茨海默病、白内障形成和动脉粥样硬化。[RefSeq 提供，2008 年 7 月]

Cytosolic and membrane-bound forms of Glutathione S-transferase are encoded by two distinct supergene families. These Enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode Enzymes with Glutathione Peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]