2. Gene
  3. GUCY1A1 - guanylate cyclase 1 soluble subunit alpha 1 Gene

GUCY1A1 - guanylate cyclase 1 soluble subunit alpha 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷酸环化酶 1 可溶性亚基 alpha 1

种属: Homo sapiens

同用名: GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A3; GCS-alpha-3; GC-S-alpha-1

基因 ID: 2982 | 基因类型: protein coding

关于 GUCY1A1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,666,848-155,737,059 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues, 17 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 11.3), heart (RPKM 8.5) and 24 other tissues.

功能概要

可溶性鸟苷酸环化酶是异源二聚体蛋白，可催化 GTP 转化为 3',5'-环 GMP 和焦磷酸盐。由该基因编码的蛋白质是该复合物的一个 α 亚基，它与一个 β 亚基相互作用形成鸟苷酸环化酶，该酶被一氧化氮激活。已发现该基因的几种转录变体编码几种不同的亚型。[RefSeq 提供，2012 年 1 月]

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the Guanylate Cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A1 基因产物(18)

mRNA Protein Name
NM_000856.6 NP_000847.2 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130682.3 NP_001124154.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130683.4 NP_001124155.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130684.3 NP_001124156.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130685.3 NP_001124157.1 guanylate cyclase soluble subunit alpha-1 isoform B
NM_001130687.3 NP_001124159.1 guanylate cyclase soluble subunit alpha-1 isoform D
NM_001256449.2 NP_001243378.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379666.1 NP_001366595.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379667.1 NP_001366596.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379668.1 NP_001366597.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379669.1 NP_001366598.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379670.1 NP_001366599.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379671.1 NP_001366600.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379672.1 NP_001366601.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379673.1 NP_001366602.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379674.1 NP_001366603.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379675.1 NP_001366604.1 guanylate cyclase soluble subunit alpha-1 isoform E
NM_001379676.1 NP_001366605.1 guanylate cyclase soluble subunit alpha-1 isoform F
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanylate cyclase activity IDA
IDA: 通过直接分析推断
23505436 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23505436 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cGMP biosynthetic process IDA
IDA: 通过直接分析推断
23505436 GOA
involved in nitric oxide-cGMP-mediated signaling IDA
IDA: 通过直接分析推断
23505436 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of guanylate cyclase complex, soluble IDA
IDA: 通过直接分析推断
23505436 GOA
part of guanylate cyclase complex, soluble IPI
IPI: 通过物理相互作用推断
23505436 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GUCY1A1 蛋白结构

HNOB

HNOB: Haem-NO-binding (90 - 234)

HNOBA

HNOBA: Heme NO binding associated (273 - 466)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (472 - 643)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
蛋白主名 其他名称

guanylate cyclase soluble subunit alpha-1

guanylate cyclase 1, soluble, alpha 3

GUCY1A1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GUCY1A1 Q02108 GUCY1B1 Homo sapiens Q02153
X-Ray Diffraction
23505436
种属内
GUCY1A1 Q02108 GUCY1B1 Homo sapiens Q02153
GTPase Assay
23505436
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Moyamoya Disease 6 With Or Without Achalasia

Moyamoya Disease With Early-Onset Achalasia

MYMY6

Moyamoya 6 With Achalasia

Moyamoya, With Achalasia, Type 6
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Achalasia

Cardiospasm

Achalasia Of Cardia

Esophageal Achalasia

Hypertensive Lower Esophageal Sphincter

Idiopathic Achalasia

Achalasia Cardia

Idiopathic Achalasia Of Esophagus

Primary Achalasia

Achalasia Of Esophagus

Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

Aperistalsis Of The Oesophagus

Achalasia Of Oesophagus

Oesophageal Achalasia

Achalasia Nos

Cardia Spasm

Cardia Achalasia

Oesophageal Cardiospasm

Oesophagus Achalasia

Reflex Cardiospasm
Bartter Syndrome, Type 2, Antenatal

Bartter Disease Type 2

BARTS2

Hyperprostaglandin E Syndrome 2

Bartter Syndrome, Type 2

Bartter Syndrome Type 2

Hypokalemic Alkalosis With Hypercalciuria Antenatal 2

Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal

Bartter Syndrome Type 2 Antenatal

Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal

Bartter Syndrome Antenatal Type 2

Bartter Syndrome Type Ii

Bartter Syndrome 2, Antenatal

Abs2

Antenatal Bartter Syndrome 2

Bartter Syndrome 2

Bs2

Hyperprostanglandin E Syndrome 2

Bartter Syndrome, Antenatal , Type 2

Antley-Bixler Syndrome, Autosomal Dominant
Hemiplegia

Infantile Hemiplegia

Postnatal Infantile Hemiplegia

Hemiplegia, Infantile
Cerebral Arterial Disease

Cerebral Arterial Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05918 GUCY1A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GUCY1A1 VGNC VGNC:67514
Rattus norvegicus GUCY1A1 RGD RGD:68436
Macaca mulatta GUCY1A1 VGNC VGNC:73327
Mus musculus GUCY1A1 MGD MGI:1926562
Bos taurus GUCY1A1 VGNC VGNC:29720
Canis familiaris GUCY1A1 VGNC VGNC:41567
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