2. Gene
  3. GUCY1B1 - guanylate cyclase 1 soluble subunit beta 1 Gene

GUCY1B1 - guanylate cyclase 1 soluble subunit beta 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷酸环化酶 1 可溶性亚基 β 1

种属: Homo sapiens

同用名: GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B3; GC-S-beta-1

基因 ID: 2983 | 基因类型: protein coding

关于 GUCY1B1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,759,021-155,807,811 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 17 paralogues. Broad expression in brain (RPKM 21.9), placenta (RPKM 13.8) and 21 other tissues.

功能概要

该基因编码可溶性鸟苷酸环化酶 (sGC) 的 β 亚基，该酶催化 GTP (三磷酸鸟苷) 转化为 cGMP (环磷酸鸟苷) 。编码的蛋白质包含一个 HNOX 结构域，它作为一氧化氮、氧气和硝基血管扩张药物等配体的受体。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 5 月]

This gene encodes the beta subunit of the soluble Guanylate Cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GUCY1B1 基因产物(6)

mRNA Protein Name
NM_000857.5 NP_000848.1 guanylate cyclase soluble subunit beta-1 isoform 2
NM_001291951.3 NP_001278880.1 guanylate cyclase soluble subunit beta-1 isoform 1
NM_001291952.3 NP_001278881.1 guanylate cyclase soluble subunit beta-1 isoform 3
NM_001291953.3 NP_001278882.1 guanylate cyclase soluble subunit beta-1 isoform 4
NM_001291954.3 NP_001278883.1 guanylate cyclase soluble subunit beta-1 isoform 5
NM_001291955.3 NP_001278884.1 guanylate cyclase soluble subunit beta-1 isoform 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanylate cyclase activity IDA
IDA: 通过直接分析推断
23505436 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23505436 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cGMP biosynthetic process IDA
IDA: 通过直接分析推断
23505436 GOA
involved in nitric oxide-cGMP-mediated signaling IDA
IDA: 通过直接分析推断
23505436 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of guanylate cyclase complex, soluble IDA
IDA: 通过直接分析推断
23505436 GOA
part of guanylate cyclase complex, soluble IPI
IPI: 通过物理相互作用推断
23505436 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GUCY1B1 蛋白结构

HNOB

HNOB: Haem-NO-binding (1 - 172)

HNOBA

HNOBA: Heme NO binding associated (203 - 406)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (413 - 604)

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  • 619 a.a.
蛋白主名 其他名称

guanylate cyclase soluble subunit beta-1

GCS-beta-1

GUCY1B1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GUCY1B1 Q02153 GUCY1A1 Homo sapiens Q02108
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

GUCY1B1 抗体

目录号 产品名 应用 反应物种
HY-P82402 Guanylyl Cyclase beta 1 Antibody (YA2147) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7
Bartter Syndrome, Type 2, Antenatal

Bartter Disease Type 2

BARTS2

Hyperprostaglandin E Syndrome 2

Bartter Syndrome, Type 2

Bartter Syndrome Type 2

Hypokalemic Alkalosis With Hypercalciuria Antenatal 2

Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal

Bartter Syndrome Type 2 Antenatal

Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal

Bartter Syndrome Antenatal Type 2

Bartter Syndrome Type Ii

Bartter Syndrome 2, Antenatal

Abs2

Antenatal Bartter Syndrome 2

Bartter Syndrome 2

Bs2

Hyperprostanglandin E Syndrome 2

Bartter Syndrome, Antenatal , Type 2

Antley-Bixler Syndrome, Autosomal Dominant
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GUCY1B1 VGNC VGNC:29721
Macaca mulatta GUCY1B1 VGNC VGNC:73328
Rattus norvegicus GUCY1B1 RGD RGD:2769
Mus musculus GUCY1B1 MGD MGI:1860604
Canis familiaris GUCY1B1 VGNC VGNC:41568
Felis catus GUCY1B1 VGNC VGNC:67515
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