1. Gene
  2. Ulk2 - unc-51 like kinase 2 Gene

Ulk2 - unc-51 like kinase 2 Gene

中文名称:unc-51 样激酶 2

种属: Mus musculus

同用名: Unc51.2; mKIAA0623; A830085I22Rik

基因 ID: 29869 | 基因类型: protein coding

关于 Ulk2

Chromosome 11: 61,666,475-61,745,899 reverse strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与自噬和对饥饿的反应。作用于轴突延伸的上游或内部以及侧枝萌芽的负调节。位于吞噬泡组装位点膜。表达于面骨原基;神经系统;和感觉器官。与人类 ULK2(unc-51 样自噬激活激酶 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in Autophagy and response to starvation. Acts upstream of or within axon extension and negative regulation of collateral sprouting. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like Autophagy activating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ulk2 基因产物(1)

mRNA Protein Name
NM_013881.4 NP_038909.3 serine/threonine-protein kinase ULK2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18443221 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18443221 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagy IMP
IMP: 通过突变表型推断
18443221 MGI
acts upstream of or within axon extension IMP
IMP: 通过突变表型推断
17389358 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
29099309 MGI
acts upstream of collateral sprouting IMP
IMP: 通过突变表型推断
17389358 MGI
acts upstream of or within negative regulation of collateral sprouting IMP
IMP: 通过突变表型推断
17389358 MGI
acts upstream of or within protein localization IGI
IGI: 通过遗传相互作用推断
29099309 MGI
involved in response to starvation IDA
IDA: 通过直接分析推断
18443221 MGI
acts upstream of or within somatic sensory system development IGI
IGI: 通过遗传相互作用推断
29099309 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in phagophore assembly site membrane IDA
IDA: 通过直接分析推断
18443221 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ulk2 蛋白结构

STKc_ULK2

STKc_ULK2: cd14201 (1 - 271)

DUF3543

DUF3543: cl13493 (842 - 1029)

  • 0
  • 200
  • 400
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  • 800
  • 1037 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase ULK2

serine/threonine-protein kinase Unc51.2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ulk2 NCBI NCBI:9706