2. Gene
  3. Iqgap1 - IQ motif containing GTPase activating protein 1 Gene

Iqgap1 - IQ motif containing GTPase activating protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mKIAA0051; D7Ertd237e; D7Ertd257e

基因 ID: 29875 | 基因类型: protein coding

关于 Iqgap1

功能概要

Enables small GTPase binding activity. Involved in cellular response to growth factor stimulus; positive regulation of protein kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within fibroblast migration; negative regulation of dephosphorylation; and regulation of cytokine production. Located in several cellular components, including cortical actin cytoskeleton; focal adhesion; and lateral plasma membrane. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and skin. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Iqgap1 基因产物(1)

mRNA Protein Name
NM_016721.2 NP_057930.2 ras GTPase-activating-like protein IQGAP1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16628219 MGI
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
18604197 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in caveola assembly IMP
IMP: 通过突变表型推断
20951348 MGI
involved in cellular response to epidermal growth factor stimulus IMP
IMP: 通过突变表型推断
17563371 MGI
involved in cellular response to fibroblast growth factor stimulus IMP
IMP: 通过突变表型推断
17563371 MGI
involved in cellular response to platelet-derived growth factor stimulus IMP
IMP: 通过突变表型推断
17563371 MGI
involved in epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17563371 MGI
involved in fibroblast growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17563371 MGI
acts upstream of or within fibroblast migration IGI
IGI: 通过遗传相互作用推断
24841562 MGI
acts upstream of or within negative regulation of dephosphorylation IGI
IGI: 通过遗传相互作用推断
21709260 MGI
involved in platelet-derived growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17563371 MGI
involved in positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
17563371 MGI
acts upstream of or within regulation of cytokine production IMP
IMP: 通过突变表型推断
21709260 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
35601831 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
35601831 MGI
located in cell leading edge IDA
IDA: 通过直接分析推断
24841562 MGI
located in cell leading edge IGI
IGI: 通过遗传相互作用推断
16369480 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
18604197 MGI
located in cortical actin cytoskeleton IPI
IPI: 通过物理相互作用推断
28089576 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
14516655 MGI
located in focal adhesion IDA
IDA: 通过直接分析推断
24841562 MGI
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
18604197 MGI
located in neuron projection IGI
IGI: 通过遗传相互作用推断
16369480 MGI
located in nucleus IDA
IDA: 通过直接分析推断
20883816 MGI
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
21709260 MGI
part of ribonucleoprotein complex IGI
IGI: 通过遗传相互作用推断
21709260 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ras GTPase-activating-like protein IQGAP1

Cdc42-Rac1 effector protein

Iqgap1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Iqgap1 Q9JKF1 Shc1 Mus musculus P98083
Far-WB
20075861
种属内
Iqgap1 Q9JKF1 Shc1 Mus musculus P98083
Pull Down
20075861
种属间
Iqgap1 Q9JKF1 gag Moloney murine leukemia virus P03332
Y2H
16628219
种属间
Iqgap1 Q9JKF1 gag Moloney murine leukemia virus P03332
Pull Down
16628219
种属间
Iqgap1 Q9JKF1 gag Moloney murine leukemia virus P03332
Anti Tag CoIP
16628219
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163707 UR778Br Inducer 99.20% 否
HY-RS06885 IQGAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Iqgap1 NCBI NCBI:8826
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