2. Gene
  3. Shc1 - src homology 2 domain-containing transforming protein C1 Gene

Shc1 - src homology 2 domain-containing transforming protein C1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Shc; p66; ShcA; p66shc

基因 ID: 20416 | 基因类型: protein coding

关于 Shc1

功能概要

Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; circulatory system development; and positive regulation of MAPK cascade. Predicted to be located in endosome membrane and nucleus. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; liver; skeleton; and skin. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Shc1 基因产物(2)

mRNA Protein Name
NM_001113331.2 NP_001106802.1 SHC-transforming protein 1 isoform a
NM_011368.5 NP_035498.2 SHC-transforming protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
12925710 MGI
enables epidermal growth factor binding IPI
IPI: 通过物理相互作用推断
15467833 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18413607 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7529871 MGI
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
12367511 MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
IDA: 通过直接分析推断
7799946 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IMP
IMP: 通过突变表型推断
10809671 MGI
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
10809671 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: 通过突变表型推断
10809671 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
23846654 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
10809671 MGI
involved in insulin-like growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
12483226 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
10809671 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23846654 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SHC-transforming protein 1

SH2 domain protein C1

SHC-transforming protein A

Shc1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Shc1 P98083 Grb2 Mus musculus Q60631
Anti Bait CoIP
18273058
种属内
Shc1 P98083 Grb2 Mus musculus Q60631
Anti Bait CoIP
11259577
种属内
Shc1 P98083 Grb2 Mus musculus Q60631
CoIP
7529871
种属内
Shc1 P98083 Grb2 Mus musculus Q60631
CoIP
10748054
种属内
Shc1 P98083 Ptpn12 Mus musculus P35831
NMR
20075861
种属内
Shc1 P98083 Shcbp1 Mus musculus Q9Z179
Y2H
15102471
种属内
Shc1 P98083 Amd1 Mus musculus P0DMN7
Y2H
15102471
种属内
Shc1 P98083 Iqgap1 Mus musculus Q9JKF1
Pull Down
20075861
种属内
Shc1 P98083 Iqgap1 Mus musculus Q9JKF1
NMR
20075861
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12856 SHC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Shc1 NCBI NCBI:6464
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