1. Gene
  2. STRN4 - striatin 4 Gene

STRN4 - striatin 4 Gene

中文名称:纹状蛋白 4

种属: Homo sapiens

同用名: ZIN; PPP2R6C; zinedin

基因 ID: 29888 | 基因类型: protein coding

关于 STRN4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,719,511-46,746,450 (from NCBI)

This gene has 24 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in testis (RPKM 42.4), spleen (RPKM 16.0) and 25 other tissues.

功能概要

启用犰狳重复域结合活性和蛋白磷酸酶 2A 结合活性。 FAR/SIN/STRIPAK 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables armadillo repeat domain binding activity and protein Phosphatase 2A binding activity. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN4 基因产物(2)

mRNA Protein Name
NM_001039877.2 NP_001034966.1 striatin-4 isoform 2
NM_013403.3 NP_037535.2 striatin-4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables armadillo repeat domain binding IPI
IPI: 通过物理相互作用推断
18502210 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20195357 GOA
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
18782753 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
32640226 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of hippo signaling IDA
IDA: 通过直接分析推断
32640226 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FAR/SIN/STRIPAK complex IDA
IDA: 通过直接分析推断
18782753 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

STRN4 蛋白结构

Striatin

Striatin: Striatin family (64 - 196)

WD40

WD40: WD domain, G-beta repeat (428 - 466)

WD40

WD40: WD domain, G-beta repeat (482 - 519)

WD40

WD40: WD domain, G-beta repeat (537 - 572)

WD40

WD40: WD domain, G-beta repeat (669 - 707)

WD40

WD40: WD domain, G-beta repeat (721 - 752)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
蛋白主名 其他名称

striatin-4

protein phosphatase 2 regulatory subunit B'''gamma

STRN4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra STRN4 Q9NRL3 JUN Homo sapiens P05412
TAP
20195357
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Muscular Dystrophy-Dystroglycanopathy , Type C, 5

Lgmd2i

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2i

MDDGC5

Limb-Girdle Muscular Dystrophy Due To Fkrp Deficiency

Limb-Girdle Muscular Dystrophy Type 2i

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 9

Lgmdr9

Muscular Dystrophy, Limb-Girdle, Type 2i

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Frkp-Related

Fkrp-Related Limb-Girdle Muscular Dystrophy R9

Fkrp-Related Lgmd R9

Lgmd Due To Fkrp Deficiency

Lgmd Type 2i

Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Frkp-Related

Muscular Dystrophy Limb-Girdle Type 2i

Muscular Dystrophy-Dystroglycanopathy Type C 5

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C5

Dystrophy, Muscular, Limb-Girdle, Type 2i

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris STRN4 VGNC VGNC:46947
Felis catus STRN4 VGNC VGNC:65803
Bos taurus STRN4 VGNC VGNC:35426
Rattus norvegicus STRN4 RGD RGD:1307030
Macaca mulatta STRN4 VGNC VGNC:78128
Mus musculus STRN4 MGD MGI:2142346