1. Gene
  2. CPSF1 - cleavage and polyadenylation specific factor 1 Gene

CPSF1 - cleavage and polyadenylation specific factor 1 Gene

中文名称:切割和聚腺苷酸化特异性因子 1

种属: Homo sapiens

同用名: MYP27; CPSF160; P/cl.18; HSU37012

基因 ID: 29894 | 基因类型: protein coding

关于 CPSF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,393,231-144,409,335 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 197 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 31.8), duodenum (RPKM 25.9) and 25 other tissues.

功能概要

切割和聚腺苷酸化特异性因子 (CPSF) 是一种多亚基复合物,在 pre-mRNA 的 3-素数加工中起着核心作用。 CPSF 识别 pre-mRNA 中的 AAUAAA 信号并与其他蛋白质相互作用以促进 RNA 切割和 poly (A) 合成。 CPSF1 是 CPSF 复合体的最大亚基 (Murthy 和 Manley,1995 [PubMed 7590244]) 。[OMIM 提供,2008 年 3 月]

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

CPSF1 基因产物(1)

mRNA Protein Name
NM_013291.3 NP_037423.2 cleavage and polyadenylation specificity factor subunit 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
7590244 GOA
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
7590244 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7590244 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: 通过直接分析推断
7590244 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CPSF1 蛋白结构

MMS1_N

MMS1_N: Mono-functional DNA-alkylating methyl methanesulfonate N-term (92 - 671)

CPSF_A

CPSF_A: CPSF A subunit region (1073 - 1408)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1443 a.a.
蛋白主名 其他名称

cleavage and polyadenylation specificity factor subunit 1

CPSF 160 kDa subunit

CPSF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CPSF1 Q10570 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra CPSF1 Q10570 REL Homo sapiens Q04864
Y2H Array
25416956
Intra CPSF1 Q10570 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra CPSF1 Q10570 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra CPSF1 Q10570 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra CPSF1 Q10570 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra CPSF1 Q10570 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra CPSF1 Q10570 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra CPSF1 Q10570 NPM1 Homo sapiens P06748
Anti Bait CoIP
21822216
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myopia 27, Autosomal Dominant

Myopia 27

MYP27

Refractive Error

Refractive Errors

Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted

Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CPSF1 VGNC VGNC:39573
Rattus norvegicus CPSF1 RGD RGD:1306406
Macaca mulatta CPSF1 VGNC VGNC:71472
Bos taurus CPSF1 VGNC VGNC:27670
Felis catus CPSF1 VGNC VGNC:82368
Mus musculus CPSF1 MGD MGI:2679722