SNX15 - sorting nexin 15 Gene

中文名称：分选 nexin 15

种属: Homo sapiens

同用名: HSAF001435

关于 SNX15

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。该基因的过度表达导致胰岛素和肝细胞生长因子受体对其成熟亚基的加工减少。这种减少是由弗林蛋白酶的错误定位引起的，弗林蛋白酶是负责切割胰岛素和肝细胞生长因子受体的内切蛋白酶。这种蛋白质参与从质膜到再循环核内体或跨高尔基体网络的核内体运输。可变剪接导致多个转录本变体。该基因与上游 ADP-核糖基化因子样 2 (ARL2) 基因之间也存在通读转录。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of Insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of Furin, the endoprotease responsible for cleavage of Insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]