1. Gene
  2. RTN4 - reticulon 4 Gene

RTN4 - reticulon 4 Gene

中文名称:网状 4

种属: Homo sapiens

同用名: ASY; NSP; NOGO; RTN-X; NSP-CL; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545

基因 ID: 57142 | 基因类型: protein coding

关于 RTN4

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:54,972,189-55,137,831 (from NCBI)

This gene has 14 transcripts (splice variants), 221 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 122.1), brain (RPKM 104.7) and 24 other tissues.

功能概要

该基因属于网状编码基因家族。网状细胞与内质网有关,并参与神经内分泌分泌或神经内分泌细胞的膜运输。该基因的产物是一种有效的神经突生长抑制剂,它也可能有助于阻止高等脊椎动物中枢神经系统的再生。已经鉴定出源自差异剪接和差异启动子使用并编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

RTN4 基因产物(11)

mRNA Protein Name
NM_001321859.2 NP_001308788.1 reticulon-4 isoform E
NM_001321860.1 NP_001308789.1 reticulon-4 isoform E
NM_001321861.2 NP_001308790.1 reticulon-4 isoform E
NM_001321862.2 NP_001308791.1 reticulon-4 isoform E
NM_001321863.2 NP_001308792.1 reticulon-4 isoform E
NM_001321904.2 NP_001308833.1 reticulon-4 isoform E
NM_007008.3 NP_008939.1 reticulon-4 isoform C
NM_020532.5 NP_065393.1 reticulon-4 isoform A
NM_153828.3 NP_722550.1 reticulon-4 isoform B
NM_207520.2 NP_997403.1 reticulon-4 isoform D
NM_207521.2 NP_997404.1 reticulon-4 isoform E
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IPI
IPI: 通过物理相互作用推断
21183689 GOA
enables metal ion binding EXP
EXP: 通过实验结果推断
15317586 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11126360 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
27786289 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
27353365 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell adhesion involved in sprouting angiogenesis IDA
IDA: 通过直接分析推断
15034570 GOA
involved in endoplasmic reticulum organization IDA
IDA: 通过直接分析推断
27786289 GOA
involved in endoplasmic reticulum tubular network formation IDA
IDA: 通过直接分析推断
24262037 GOA
involved in endoplasmic reticulum tubular network membrane organization IMP
IMP: 通过突变表型推断
27619977 GOA
involved in endoplasmic reticulum tubular network organization IMP
IMP: 通过突变表型推断
18779370 GOA
involved in negative regulation of amyloid-beta formation IDA
IDA: 通过直接分析推断
15286784 GOA
involved in negative regulation of axon extension IDA
IDA: 通过直接分析推断
10667797 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
20463223 GOA
involved in nuclear pore complex assembly IMP
IMP: 通过突变表型推断
26906412 GOA
involved in positive regulation of ERBB3 signaling pathway IMP
IMP: 通过突变表型推断
27353365 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
27353365 GOA
involved in positive regulation of mammary gland epithelial cell proliferation IMP
IMP: 通过突变表型推断
27353365 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
27353365 GOA
involved in positive regulation of protein localization to endoplasmic reticulum IDA
IDA: 通过直接分析推断
27353365 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
27353365 GOA
acts upstream of or within regulation of cell migration IDA
IDA: 通过直接分析推断
15034570 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell junction IDA
IDA: 通过直接分析推断
21183689 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
10667797 GOA
located in endoplasmic reticulum tubular network IDA
IDA: 通过直接分析推断
27353365 GOA
located in endoplasmic reticulum tubular network membrane IDA
IDA: 通过直接分析推断
27619977 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
11126360 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
15034570 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RTN4 蛋白结构

Reticulon

Reticulon: Reticulon (1005 - 1174)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1192 a.a.
蛋白主名 其他名称

reticulon-4

Human NogoA

RTN4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RTN4 Q9NQC3 SYT16 Homo sapiens Q17RD7 29892012
种属内
RTN4 Q9NQC3 SYT16 Homo sapiens Q17RD7 31515488
种属内
RTN4 Q9NQC3 SYT16 Homo sapiens Q17RD7 25416956
种属内
RTN4 Q9NQC3 SYT16 Homo sapiens Q17RD7 25416956
种属内
RTN4 Q9NQC3 RTN2 Homo sapiens O75298 35271311
种属内
RTN4 Q9NQC3 RTN2 Homo sapiens O75298 33961781
种属内
RTN4 Q9NQC3 SNX1 Homo sapiens Q13596 25416956
种属内
RTN4 Q9NQC3 ZFYVE21 Homo sapiens Q9BQ24 25416956
种属内
RTN4 Q9NQC3 ARL6IP1 Homo sapiens Q15041 33961781
种属内
RTN4 Q9NQC3 ARL6IP1 Homo sapiens Q15041 25416956
种属内
RTN4 Q9NQC3 SNX15 Homo sapiens Q9NRS6 25416956
种属内
RTN4 Q9NQC3 SNX15 Homo sapiens Q9NRS6 25416956
种属内
RTN4 Q9NQC3 CERT1 Homo sapiens Q9Y5P4 29892012
种属内
RTN4 Q9NQC3 CERT1 Homo sapiens Q9Y5P4 31515488
种属内
RTN4 Q9NQC3 RTN3 Homo sapiens O95197 35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

RTN4 抗体

目录号 产品名 应用 反应物种
HY-P81675 Nogo Antibody (YA1420) WB, IHC-P, ICC/IF, IP, FC Human

关联疾病

疾病名称 别名
Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

Anosognosia
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10

Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures

Optic Atrophy 10

Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Cholestasis, Intrahepatic, Of Pregnancy 3

ICP3

Cholestasis, Intrahepatic, Of Pregnancy, 3

Intrahepatic Cholestasis Of Pregnancy 3

Pregnancy Related Cholestasis 3

Cholestasis Of Pregnancy, Intrahepatic 3

Cholestasis, Intrahepatic, Of Pregnancy, Type 3

Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2

Hsan2

HSAN2A

Morvan Disease

Hereditary Sensory And Autonomic Neuropathy Type Ii

Neurogenic Acroosteolysis

Hsan Iia

Hsn2a

Hsn Iia

Neuropathy, Progressive Sensory, Of Children

Neuropathy, Congenital Sensory

Neuropathy, Hereditary Sensory And Autonomic, Type Ii

Hereditary Sensory And Autonomic Neuropathy Type 2a

Hereditary Sensory And Autonomic Neuropathy Type Iia

Hsanii

Congenital Sensory Neuropathy

Hsan Type Ii

Morvan Syndrome

Neuropathy, Hereditary Sensory And Autonomic, Type 2a

Morvan'S Disease

Neuropathy, Hereditary Sensory, Type Iia

Acroosteolysis, Neurogenic

Acroosteolysis, Giaccai Type

Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive

Hereditary Sensory Autonomic Neuropathy Type 2

Giaccai Type Acroosteolysis

Hereditary Sensory Neuropathy Type 2

Hereditary Sensory Radicular Neuropathy, Recessive Form

Hsan2b

Hsan2c

Hsan2d

Hsn Type Ii

Autosomal Recessive Sensory Radicular Neuropathy

Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome

Morvan Fibrillary Chorea

Neuropathy, Hereditary Sensory And Autonomic, 2a

Acroosteolysis Giaccai Type

Hereditary Sensory Neuropathy Type Iia

Hereditary Sensory Radicular Neuropathy Autosomal Recessive

Progressive Sensory Neuropathy Of Children

Neuropathy Congenital Sensory

Charcot-Marie-Tooth Disease

Neuropathy, Sensory And Autonomic, Hereditary, Type Iia

Hereditary Sensory Autonomic Neuropathy, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Sensory Neuropathy, Hereditary

Neuropathy, Hereditary Sensory And Autonomic, Type Iib

Cardiomyopathy, Dilated, 1dd

Dilated Cardiomyopathy 1dd

CMD1DD

Cardiomyopathy, Dilated 1dd

Cardiomyopathy, Dilated, Type 1dd

Kleptomania

Pathological Stealing

Syringomyelia

Hydromyelia

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RTN4 VGNC VGNC:106215
Felis catus RTN4 VGNC VGNC:81215
Bos taurus RTN4 VGNC VGNC:106907
Mus musculus RTN4 MGD MGI:1915835
Rattus norvegicus RTN4 RGD RGD:620989
Canis familiaris RTN4 VGNC VGNC:54541
Macaca fascicularis RTN4 NCBI NCBI:101865007
Others RTN4 NCBI