1. Gene
  2. Tert - telomerase reverse transcriptase Gene

Tert - telomerase reverse transcriptase Gene

中文名称:端粒酶逆转录酶

种属: Rattus norvegicus

基因 ID: 301965 | 基因类型: protein coding

关于 Tert

Primary_assembly 1: 29,637,506-29,659,561 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 188 orthologues and is associated with 103 phenotypes. Biased expression in Liver (RPKM 26.6), Thymus (RPKM 16.6) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能,包括伴侣结合活动;核酸结合活性;和核苷酸转移酶活性。参与多个过程,包括细胞凋亡过程的负调控;转分化的正调控;血管相关平滑肌细胞迁移的正向调节。位于线粒体和细胞核中。用于研究慢性肾病和短暂性脑缺血。肝细胞癌和肺动脉高压的生物标志物。该基因的人类直系同源物与多种疾病有关,包括常染色体显性先天性角化不良 2;家族性黑色素瘤;肝细胞癌;特发性肺纤维化;和白血病(多种)。与人类 TERT(端粒酶逆转录酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including chaperone binding activity; nucleic acid binding activity; and nucleotidyltransferase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of transdifferentiation; and positive regulation of vascular associated smooth muscle cell migration. Located in mitochondrion and nucleus. Used to study chronic kidney disease and transient cerebral ischemia. Biomarker of hepatocellular carcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase Reverse Transcriptase). [provided by Alliance of Genome Resources, Apr 2022]

Tert 基因产物(1)

mRNA Protein Name
NM_053423.2 NP_445875.1 telomerase reverse transcriptase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23184978 RGD
enables telomerase activity IDA
IDA: 通过直接分析推断
9665809 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
21937513 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Tert 蛋白结构

Telomerase_RBD

Telomerase_RBD: pfam12009 (453 - 584)

TERT

TERT: cd01648 (819 - 932)

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  • 1129 a.a.
蛋白主名 其他名称

telomerase reverse transcriptase

telomerase catalytic subunit

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tert NCBI NCBI:7015
Mus musculus Tert NCBI NCBI:21752