2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation
  3. MEK ERK AP-1
  4. TERT activator-1

TERT activator-1 

目录号: HY-402361 纯度: 99.50%
COA 产品使用指南

摩尔计算器

TERT activator-1 是端粒酶逆转录酶 (TERT) 的小分子激活剂，可通过 MEK/ERK/AP-1 信号级联促进 TERT 的转录。TERT activator-1 能够促进成体神经发生和增强神经肌肉。TERT activator-1 可减轻高龄小鼠的细胞衰老和全身炎症，可用于衰老的研究。

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TERT activator-1 Chemical Structure

TERT activator-1 Chemical Structure

CAS No. : 666699-46-3

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规格 价格 是否有货 数量
5 mg ￥1150
In-stock
10 mg ￥1850
In-stock
25 mg ￥3750
In-stock
50 mg ￥6000
In-stock
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200 mg   询价  

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Customer Review

TERT activator-1 相关抗体

Top Publications Citing Use of Products

查看 MEK 亚型特异性产品:

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MEK1 MEK2 MEK5 MEK

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

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c-Fos c-Jun

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1].

IC50 & Target[1]

MEK1

 

MEK2

 

ERK1

 

ERK2

 

体外研究
(In Vitro)

TERT activator-1 (0-10 μM；0-4 小时) 在 MRC-5 细胞中通过 MEK/ERK/AP-1 通路特异性激活 TERT 的转录，并可改变 TERT 启动子区域的染色质状态[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TERT activator-1 相关抗体:

Real Time qPCR[1]

Cell Line: MRC-5 human fibroblasts cells
Concentration: 0, 0.05, 0.1, 0.5, 1, 5 and 10 μM
Incubation Time: 4 h
Result: Reduced the mRNA levels of TERT.
体内研究
(In Vivo)

TERT activator-1 (6 mg/kg；腹腔注射；1-6 周) 在自然衰老小鼠中缓解衰老和促进成体神经发生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 10-12 weeks old[1]
Dosage: 6 mg/kg
Administration: Intraperitoneal injection (i.p.); 1 week
Result: Significantly increased the level of TERT protein.
Reduced aging genetic traits including cell-cycle arrest and PML body.
Suppressed p16Ink4a and other senescence-associated secretory phenotype (SASP) components.
Induced signatures of organism growth and natural killer cell activation.
Increased in the levels of mBDNF in adult hippocampus.
Animal Model: Naturally aged C57BL/6 mice aged 20-21 months old[1]
Dosage: 6 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times a week; 6 months
Result: Improves hippocampal-dependent cognitive function.
Enhances neuromuscular function.
Did not result in any overt adverse consequences.
分子量

331.77

Formula

C14H12ClF2NO2S
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.50%

COA (288 KB) HNMR (219 KB) RP-HPLC (251 KB) LCMS (143 KB)

产品使用指南 (1538 KB)
参考文献

TERT activator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TERT activator-1666699-46-3TERT activator1TERT activator 1MEKERKAP-1Mitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesActivator Protein 1TERT activatorAgingAdult neurogenesisInhibitorinhibitorinhibit

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目录号：
HY-402361
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